ArticleJournal of virology2008
Cleavage of group 1 coronavirus spike proteins: how furin cleavage is traded off against heparan sulfate binding upon cell culture adaptation.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 125 citations in OpenAlex.
- OC43 clinical isolate spike proteins have distinct carbohydrate-binding properties.Nature communications · 2026Article
- Emergence of a Highly Virulent Porcine Epidemic Diarrhea Virus (PEDV) G2c Subtype in China: Isolation, Genetic and Pathogenic Characterization, and Cross-Neutralizing Antibody Response.Transboundary and emerging diseases · 2026Article
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- Mechanism, structural and functional insights into nidovirus-induced double-membrane vesicles.Frontiers in immunology · 2024Review
- Pteropine orthoreoviruses use cell surface heparan sulphate as an attachment receptor.Emerging microbes & infections · 2023Article
- Characterization of monoclonal antibodies against porcine epidemic diarrhea virus S1/S2 junction protein.AMB Express · 2023Article
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- The role of influenza-A virus and coronavirus viral glycoprotein cleavage in host adaptation.Current opinion in virology · 2023Review
- Respiratory viruses interacting with cells: the importance of electrostatics.Frontiers in microbiology · 2023Review
- Glycosylation in SARS-CoV-2 variants: A path to infection and recovery.Biochemical pharmacology · 2022Review
- Establishment of enzyme-linked immunosorbent assays based on recombinant S1 and its truncated proteins for detection of PEDV IgA antibody.BMC veterinary research · 2022Article
- Is heparan sulfate a target for inhibition of RNA virus infection?American journal of physiology. Cell physiology · 2022Review
- Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases.Journal of virology · 2022Article
- Review
- Article
- The Emergence of the Spike Furin Cleavage Site in SARS-CoV-2.Molecular biology and evolution · 2022Review
- Role of Q675H Mutation in Improving SARS-CoV-2 Spike Interaction with the Furin Binding Pocket.Viruses · 2021Article
- Natural and Recombinant SARS-CoV-2 Isolates Rapidly EvolveJournal of virology · 2021Article
- Cell Entry of Animal Coronaviruses.Viruses · 2021Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A longstanding enigmatic feature of the group 1 coronaviruses is the uncleaved phenotype of their spike protein, an exceptional property among class I fusion proteins. Here, however, we show that some group 1 coronavirus spike proteins carry a furin enzyme recognition motif and can actually be cleaved, as demonstrated for a feline coronavirus. Interestingly, this feature can be lost during cell culture adaptation by a single mutation in the cleavage motif; this, however, preserves a heparan sulfate binding motif and renders infection by the virus heparan sulfate dependent. We identified a similar cell culture adaptation for the human coronavirus OC43.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.