ReviewClinical microbiology reviews2008
Anisakis simplex: from obscure infectious worm to inducer of immune hypersensitivity.
Review in Clinical microbiology reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
177 citing papers in PubMed, 1 synthesis or guideline pooled it, 567 citations in OpenAlex.
- Anisakis sensitization in different population groups and public health impact: A systematic review.PloS one · 2018Pooled it
- Methods for the detection of anisakid material in different food matrices: A systematic review.Food and waterborne parasitology · 2026Review
- Experimental pathogenicity ofFood and waterborne parasitology · 2026Article
- Article
- From fish to fork: An analysis of the fishmeal feed chain & presence of Anisakid material.Food and waterborne parasitology · 2026Review
- Incidental Detection of Asymptomatic Colonic Anisakiasis During Surveillance Colonoscopy: A Case Report and Literature Review.Clinical case reports · 2026Article
- Developmental and geographic transcriptomic variation in Anisakis simplex (s. s.) reveals lncRNA-mediated regulation of mRNA expression.Scientific reports · 2026Article
- Genetic characterization ofInternational journal for parasitology. Parasites and wildlife · 2026Article
- The photodynamic inactivation in the control of the seafood zoonotic parasite, Anisakis sp.Parasitology research · 2026Article
- Prevalence of fish parasites from Lake Hawassa, Ethiopia.PloS one · 2026Article
- Persistent asymptomatic eosinophilia after raw seafood exposure with normal IgE: a case report.Frontiers in immunology · 2026Article
- Article
- In Vitro Control of Anisakis Larvae Using Nanoemulsified Thyme, Garlic, and Grape Seed Essential Oils Combined with Brines.Acta parasitologica · 2025Article
- Coupled transcriptome and proteome analysis of L3 and L4 developmental stages of Anisakis simplex s. s.: insights into target genes under glucose influence.BMC genomics · 2025Article
- Food Safety Concerns:Pathogens (Basel, Switzerland) · 2025Article
- The Role ofPathogens (Basel, Switzerland) · 2025Article
- Occurrence of parasites in fishery species along the Moroccan coastline.Italian journal of food safety · 2025Article
- Invasion dynamics and ecological impacts ofVeterinary world · 2025Article
- Immunogenicity ofEwha medical journal · 2025Article
- Evaluating fatty acid profiles in anisakid nematode parasites and adjacent tissue of European hake (Merluccius merluccius): a first insight into local host-parasite lipid dynamics.Parasitology research · 2025Article
117 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection of humans with the nematode worm parasite Anisakis simplex was first described in the 1960s in association with the consumption of raw or undercooked fish. During the 1990s it was realized that even the ingestion of dead worms in food fish can cause severe hypersensitivity reactions, that these may be more prevalent than infection itself, and that this outcome could be associated with food preparations previously considered safe. Not only may allergic symptoms arise from infection by the parasites ("gastroallergic anisakiasis"), but true anaphylactic reactions can also occur following exposure to allergens from dead worms by food-borne, airborne, or skin contact routes. This review discusses A. simplex pathogenesis in humans, covering immune hypersensitivity reactions both in the context of a living infection and in terms of exposure to its allergens by other routes. Over the last 20 years, several studies have concentrated on A. simplex antigen characterization and innate as well as adaptive immune response to this parasite. Molecular characterization of Anisakis allergens and isolation of their encoding cDNAs is now an active field of research that should provide improved diagnostic tools in addition to tools with which to enhance our understanding of pathogenesis and controversial aspects of A. simplex allergy. We also discuss the potential relevance of parasite products such as allergens, proteinases, and proteinase inhibitors and the activation of basophils, eosinophils, and mast cells in the induction of A. simplex-related immune hypersensitivity states induced by exposure to the parasite, dead or alive.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.