ReviewClinical microbiology reviews2008
Central nervous system tuberculosis: pathogenesis and clinical aspects.
Review in Clinical microbiology reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 259 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
259 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pituitary tuberculosis in the pediatric population: a systematic review and case report.Pituitary · 2025Pooled it
- The relationship between mental health and risk of active tuberculosis: a systematic review.BMJ open · 2022Pooled it
- Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Brain MRI findings in relation to clinical characteristics and outcome of tuberculous meningitis.PloS one · 2020Trial
- Navigating complex presentations of central nervous system tuberculosis: A two-case analysis.Radiology case reports · 2026Article
- Etiologic diagnosis of suspected tuberculous meningitis by multiplex PCR of cerebrospinal fluid.Journal of clinical microbiology · 2026Article
- Multifocal tuberculosis with cerebral, spinal, pulmonary and abdominal involvement in a 16-year-old girl: A radiological case report.Radiology case reports · 2026Article
- Masked invaders: A case series on uncommon manifestations of extrapulmonary tuberculosis.Lung India : official organ of Indian Chest Society · 2026Article
- Meningeal tuberculoma presenting as a space-occupying lesion in an immuno-competent young adult patient: A case report and literature review.Radiology case reports · 2026Article
- Clinicopathological Spectrum of Brain Parenchymal Infections: A Retrospective Analytical Study.Cureus · 2026Article
- Role of Advanced Multimodality Synthetic MRI and Dynamic Contrast-Enhanced MRI Derived Parameters in the Differentiating Neurocysticercosis and Tuberculomas.Clinical neuroradiology · 2026Article
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- Case report: CNS tuberculoma in a patient with prior pulmonary tuberculosis.QJM : monthly journal of the Association of Physicians · 2026Article
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- Cerebellar Tuberculoma as a Rare Manifestation of Central Nervous System Tuberculosis: Literature Review and Clinical Case.Diagnostics (Basel, Switzerland) · 2026Article
- Right Temporal Lobe Tuberculoma Presenting as Seizures in a Patient With Pulmonary Tuberculosis.The American journal of case reports · 2026Article
- Medulloblastoma masquerading as tuberculous meningitis in a pediatric patient.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Predictors of mortality in CNS tuberculosis: clinical and radiological parameters.BMC neurology · 2026Article
199 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberculosis of the central nervous system (CNS) is a highly devastating form of tuberculosis, which, even in the setting of appropriate antitubercular therapy, leads to unacceptable levels of morbidity and mortality. Despite the development of promising molecular diagnostic techniques, diagnosis of CNS tuberculosis relies largely on microbiological methods that are insensitive, and as such, CNS tuberculosis remains a formidable diagnostic challenge. Insights into the basic neuropathogenesis of Mycobacterium tuberculosis and the development of an appropriate animal model are desperately needed. The optimal regimen and length of treatment are largely unknown, and with the rising incidence of multidrug-resistant strains of M. tuberculosis, the development of well-tolerated and effective antibiotics remains a continued need. While the most widely used vaccine in the world largely targets this manifestation of tuberculosis, the BCG vaccine has not fulfilled the promise of eliminating CNS tuberculosis. We put forth this review to highlight the current understanding of the neuropathogenesis of M. tuberculosis, to discuss certain epidemiological, clinical, diagnostic, and therapeutic aspects of CNS tuberculosis, and also to underscore the many unmet needs in this important field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.