ArticleMicrobes and infection2008
Decreased inflammatory response in Toll-like receptor 2 knockout mice is associated with exacerbated Pneumocystis pneumonia.
Article in Microbes and infection, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Targeting β-glucans, vital components of theFrontiers in immunology · 2023Review
- Clearance of Pneumocystis murina infection is not dependent on MyD88.Microbes and infection · 2014Article
- MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Accumulation of myeloid-derived suppressor cells in the lungs during Pneumocystis pneumonia.Infection and immunity · 2012Article
- Fungal pathogens-a sweet and sour treat for toll-like receptors.Frontiers in cellular and infection microbiology · 2012Review
- Toll like receptors in diseases of the lung.International immunopharmacology · 2011Review
- Defective nitric oxide production by alveolar macrophages during Pneumocystis pneumonia.American journal of respiratory cell and molecular biology · 2011Article
- Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Decreased pulmonary inflammation following ethanol and burn injury in mice deficient in TLR4 but not TLR2 signaling.Alcoholism, clinical and experimental research · 2010Article
- Downregulation of PU.1 leads to decreased expression of Dectin-1 in alveolar macrophages during Pneumocystis pneumonia.Infection and immunity · 2010Article
- Current understanding of Pneumocystis immunology.Future microbiology · 2010Review
- The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina.Infection and immunity · 2009Article
- Pneumocystis mediates overexpression of antizyme inhibitor resulting in increased polyamine levels and apoptosis in alveolar macrophages.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Pneumocystis pneumonia (PcP) is marked by substantial inflammatory damage to the lung. We have found that Toll-like receptor 2 (TLR2) mediates macrophage inflammatory responses to Pneumocystis and hypothesized that TLR2 deficiency would lead to less severe inflammation and milder lung injury during PcP. Histopathology examination showed that TLR2-/- mice with PcP indeed exhibited milder pulmonary inflammation. TLR2-/- mouse lungs contained less TNF-alpha and displayed lower levels of NF-kappaB activation during PcP. However, TLR2-/- mice with PcP displayed increased severity in symptoms and organism burden. The increased organism burden is likely due to defects in protective mechanisms in TLR2-/- mice. mRNA levels of the inducible nitric oxide synthase and NADPH oxidase p47phox, as well as nitric oxide levels in the lungs, were decreased in TLR2-/- PcP mice. Taken together, this study shows that TLR2-mediated inflammatory responses contribute to a certain degree to the clearance of Pneumocystis organism in mice.
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Registered trials
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