ArticleNeuron2008
Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons.
Article in Neuron, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 82 citations in OpenAlex.
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- Gene regulatory networks during the development of the Drosophila visual system.Current topics in developmental biology · 2020Review
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- N-Cadherin Orchestrates Self-Organization of Neurons within a Columnar Unit in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits.Neuron · 2018Article
- Purification of Low-abundant Cells in the Drosophila Visual System.Journal of visualized experiments : JoVE · 2018Article
- Strategies for assembling columns and layers in the Drosophila visual system.Neural development · 2018Review
- Juvenile hormone reveals mosaic developmental programs in the metamorphosing optic lobe ofBiology open · 2018Article
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- Vagus Motor Neuron Topographic Map Determined by Parallel Mechanisms of hox5 Expression and Time of Axon Initiation.Current biology : CB · 2017Article
- Spatio-temporal pattern of neuronal differentiation in the Drosophila visual system: A user's guide to the dynamic morphology of the developing optic lobe.Developmental biology · 2017Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The organization of neuronal processes into a series of layers is a hallmark of many brain regions. Homophilic cell adhesion molecules of the cadherin family have been implicated in layer choice. How they contribute to the targeting of neurons to distinct layers remains unclear. Here we systematically explore the role of a classical cadherin, Drosophila N-cadherin (CadN), in the targeting of five classes of related neurons to a series of consecutive layers in the fly visual system. We show that CadN is required in lamina neurons at discrete developmental steps but not used in a layer-specific fashion. Local CadN expression patterns correlate with specific growth cone movements, and CadN expression on one growth cone in a specific layer is essential for the targeting of processes of another neuron to this layer. We propose that dynamic regulation of CadN enables this widely expressed protein to mediate specific local interactions during neural circuit assembly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.