ArticleBrain pathology (Zurich, Switzerland)2009
Strain-associated variations in abnormal PrP trafficking of sheep scrapie.
Article in Brain pathology (Zurich, Switzerland), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets.Microbiology and molecular biology reviews : MMBR · 2025Review
- Review
- Evidence for preexisting prion substrain diversity in a biologically cloned prion strain.PLoS pathogens · 2023Article
- Reflections on Cerebellar Neuropathology in Classical Scrapie.Biomolecules · 2021Review
- Implications of peptide assemblies in amyloid diseases.Chemical Society reviews · 2017Review
- PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection.Journal of virology · 2017Article
- Prenatal transmission of scrapie in sheep and goats: A case study for veterinary public health.Open veterinary journal · 2016Review
- Ultrastructural changes in the progress of natural Scrapie regardless fixation protocol.Histochemistry and cell biology · 2015Article
- Glycosylphosphatidylinositol anchoring directs the assembly of Sup35NM protein into non-fibrillar, membrane-bound aggregates.The Journal of biological chemistry · 2014Article
- Pathology of SSLOW, a transmissible and fatal synthetic prion protein disorder, and comparison with naturally occurring classical transmissible spongiform encephalopathies.Neuropathology and applied neurobiology · 2014Article
- Prions and the potential transmissibility of protein misfolding diseases.Annual review of microbiology · 2013Review
- Membrane toxicity of abnormal prion protein in adrenal chromaffin cells of scrapie infected sheep.PloS one · 2013Article
- Early increase and late decrease of purkinje cell dendritic spine density in prion-infected organotypic mouse cerebellar cultures.PloS one · 2013Article
- Article
- Mechanism of PrP-amyloid formation in mice without transmissible spongiform encephalopathy.Brain pathology (Zurich, Switzerland) · 2012Article
- Article
- Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent.The Journal of biological chemistry · 2010Article
- Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring.PLoS pathogens · 2010Article
- GPI anchoring facilitates propagation and spread of misfolded Sup35 aggregates in mammalian cells.The EMBO journal · 2010Article
- Scrapie affects the maturation cycle and immune complex trapping by follicular dendritic cells in mice.PloS one · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prion diseases are associated with the accumulation of an abnormal form of the host-coded prion protein (PrP). It is postulated that different tertiary or quaternary structures of infectious PrP provide the information necessary to code for strain properties. We show here that different light microscopic types of abnormal PrP (PrP(d)) accumulation found in each of 10 sheep scrapie cases correspond ultrastructurally with abnormal endocytosis, increased endo-lysosomes, microfolding of plasma membranes, extracellular PrP(d) release and intercellular PrP(d) transfer of neurons and/or glia. The same accumulation patterns of PrP(d) and associated subcellular lesions were present in each of two scrapie strains present, but they were present in different proportions. The observations suggest that different trafficking pathways of PrP(d) are influenced by strain and cell type and that a single prion strain causes several PrP(d)-protein interactions at the cell membrane. These results imply that strains may contain or result in production of multiple isoforms of PrP(d).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.