Evidence map›Paper›PMID 18400010›Full record

ArticleFEMS immunology and medical microbiology2008

Respiratory infection with Francisella novicida induces rapid dystrophic cardiac calcinosis (DCC).

Kimberly M Roth, Steve Oghumu, Anjali A Satoskar, John S Gunn, Nico van Rooijen, Abhay R Satoskar

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEMS immunology and medical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kimberly M RothDepartment of Microbiology, The Ohio State University, Columbus, OH 43210, USA.
Steve Oghumu
Anjali A Satoskar
John S Gunn
Nico van Rooijen
Abhay R Satoskar
The Ohio State University · USUniversity of Amsterdam · NL

Funding

Vaccines and Therapies Against BotulismU54AI057153 · NIAID · UNIVERSITY OF CHICAGO · PI KANABROCKI, JOSEPH A. · 2003 to 2013
$87.6M
Mechanisms of sex-determined resistance to L. mexicanaR01AI051823 · NIAID · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R. · 2002 to 2005
$954k
NIAID NIH HHS 1-U54-AI-057153NIAID NIH HHS R01 AI051823NIAID NIH HHS U54 AI057153
6 · The paper itself

Abstract

Francisella tularensis causes pulmonary tularemia and death in humans when left untreated. Here, using a novel aerosol infection model, we show that acute pulmonary Francisella novicida infection not only causes pneumonia and liver damage, but also induces dystrophic cardiac calcinosis (DCC) in BALB/c mice. C57BL/6 mice also develop pneumonia and hepatic damage, but fail to develop DCC. Development of DCC in BALB/c mice is associated with significant induction of RANKL but not osteopontin in their organs. Depletion of lung macrophages prior to infection markedly reduces pericarditis and calcification in BALB/c mice but does not increase their susceptibility to infection.

Indexed as

AnimalsCalcinosisCardiomyopathiesFemaleFrancisellaGram-Negative Bacterial InfectionsInterleukin-1Interleukin-6LiverLungMacrophagesMaleMiceMice, Inbred BALB CMice, Inbred C57BLOsteopontinInterleukin-1Interleukin-6OsteopontinRANK LigandRNA, MessengerSpp1 protein, mouseTnfsf11 protein, mouseTumor Necrosis Factor-alpha

Identifiers

PMID18400010
PMCPMC3677074
OpenAlexW2089715498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.