ReviewInternational journal of andrology2008
An evolutionary perspective on Y-chromosomal variation and male infertility.
Review in International journal of andrology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Study on the influence of the sY1192 gene locus in the AZFb/c region on sperm quality and pregnancy outcome.Asian journal of andrology · 2025Article
- The Conceivable Functions of Protein Ubiquitination and Deubiquitination in Reproduction.Frontiers in physiology · 2022Review
- Y chromosome copy number variation and its effects on fertility and other health factors: a review.Translational andrology and urology · 2021Review
- A novel swine sex-linked marker and its application across different mammalian species.Transgenic research · 2020Article
- Landscape of RNA editing reveals new insights into the dynamic gene regulation of spermatogenesis.Cell cycle (Georgetown, Tex.) · 2019Article
- TSPY1 suppresses USP7-mediated p53 function and promotes spermatogonial proliferation.Cell death & disease · 2018Article
- Associations between male infertility and ancestry in South Americans: a case control study.BMC medical genetics · 2017Article
- Spermatogenic failure and the Y chromosome.Human genetics · 2017Review
- The pig X and Y Chromosomes: structure, sequence, and evolution.Genome research · 2016Article
- Copy number variation and microdeletions of the Y chromosome linked genes and loci across different categories of Indian infertile males.Scientific reports · 2015Article
- A comprehensive review of genetics and genetic testing in azoospermia.Clinics (Sao Paulo, Brazil) · 2013Review
- The Y chromosome-linked copy number variations and male fertility.Journal of endocrinological investigation · 2011Review
- Complex transcriptional control of the AZFa gene DDX3Y in human testis.International journal of andrology · 2011Article
- Article
- TSPY and Male Fertility.Genes · 2010Article
- Examination of disease-based selection, demographic history and population structure in European Y-chromosome haplogroup I.Journal of human genetics · 2010Article
- Epigenetic regulatory mechanisms associated with infertility.Obstetrics and gynecology international · 2010Article
- Genetic dissection of the AZF regions of the human Y chromosome: thriller or filler for male (in)fertility?Journal of biomedicine & biotechnology · 2010Review
- TSPY1 copy number variation influences spermatogenesis and shows differences among Y lineages.The Journal of clinical endocrinology and metabolism · 2009Article
- The AZFc region of the Y chromosome: at the crossroads between genetic diversity and male infertility.Human reproduction updateReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Genetic variation on the Y chromosome is one of the best-documented causes of male infertility, but the genes responsible have still not been identified. This review discusses how an evolutionary perspective may help with interpretation of the data available and suggest novel approaches to identify key genes. Comparison with the chimpanzee Y chromosome indicates that USP9Y is dispensable in apes, but that multiple copies of TSPY1 may have an important role. Comparisons between infertile and control groups in search of genetic susceptibility factors are more complex for the Y chromosome than for the rest of the genome because of population stratification and require unusual levels of confirmation. But the extreme population stratification exhibited by the Y also allows populations particularly suitable for some studies to be identified, such as the partial AZFc deletions common in Northern European populations where further dissection of this complex structural region would be facilitated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.