ArticleMolecular microbiology2008
The long strange trip of Borrelia burgdorferi outer-surface protein C.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages.Infection and immunity · 2015Article
- Evolutionary aspects of emerging Lyme disease in Canada.Applied and environmental microbiology · 2015Review
- Tick-borne Diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and Austrian Dogs: Status quo and Review of Distribution, Transmission, Clinical Findings, Diagnostics and Prophylaxis.Parasitology research · 2015Article
- Evolution and population genomics of the Lyme borreliosis pathogen, Borrelia burgdorferi.Trends in genetics : TIG · 2015Review
- Measurements of mRNA degradation in Borrelia burgdorferi.Journal of bacteriology · 2013Article
- An inverted repeat in the ospC operator is required for induction in Borrelia burgdorferi.PloS one · 2013Article
- The role of Borrelia burgdorferi outer surface proteins.FEMS immunology and medical microbiology · 2012Review
- OspC is potent plasminogen receptor on surface of Borrelia burgdorferi.The Journal of biological chemistry · 2012Article
- Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission.PLoS pathogens · 2012Article
- Genome stability of Lyme disease spirochetes: comparative genomics of Borrelia burgdorferi plasmids.PloS one · 2012Article
- Genetics of Borrelia burgdorferi.Annual review of genetics · 2012Review
- Disulfide-mediated oligomer formation in Borrelia burgdorferi outer surface protein C, a critical virulence factor and potential Lyme disease vaccine candidate.Clinical and vaccine immunology : CVI · 2011Article
- Outer surface protein C is a dissemination-facilitating factor of Borrelia burgdorferi during mammalian infection.PloS one · 2010Article
- BmpA is a surface-exposed outer-membrane protein of Borrelia burgdorferi.FEMS microbiology letters · 2010Article
- Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment.Molecular microbiology · 2010Article
- Characterization of the highly regulated antigen BBA05 in the enzootic cycle of Borrelia burgdorferi.Infection and immunity · 2010Article
- Who is the BosR around here anyway?Molecular microbiology · 2009Article
- OspC-independent infection and dissemination by host-adapted Borrelia burgdorferi.Infection and immunity · 2009Article
- Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi.Molecular microbiology · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Borrelia burgdorferi must adapt physiologically to two markedly different host milieus and efficiently transit between its mammalian host and arthropod vector during tick feeding. Differential production of lipoproteins is essential for spirochaetes to survive, multiply and migrate within both hosts. Outer-surface protein C (OspC), which is induced during the blood meal, is critical for transmission of Lyme disease spirochaetes by nymphal ticks. Its biological function is poorly understood, however, despite the fact that its crystal structure has been solved. Evidence has accumulated that OspC blocks clearance of spirochaetes following inoculation in skin, and it is thought to do so by facilitating evasion of innate immunity. The study by Liang and co-workers in this edition of Molecular Microbiology extends this work by showing that OspC prevents early elimination and promotes dissemination. Surprisingly, they also show that unrelated borrelial outer-surface lipoproteins can replace these functions in an ospC mutant. They propose that an abundance of lipoprotein(s) is needed to stabilize the borrelial outer membrane against innate defences. This provocative work clearly runs counter to prevailing orthodoxies of bacterial pathogenesis. It also points the way towards future studies that will clarify the 'partially specific' roles of this enigmatic molecule in Lyme disease pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.