ArticlePLoS biology2008
Rapid encoding and perception of novel odors in the rat.
Article in PLoS biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.
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Who cites it
127 citing papers in PubMed, 214 citations in OpenAlex.
- Target-dependent routing of sensory information in the olfactory system.Communications biology · 2026Article
- Rapid odorant metabolism organizes identity- and timing-based odor representations by olfactory bulb inputs and outputs.bioRxiv : the preprint server for biology · 2026Article
- Dexterous single sniffs for ethological active olfaction.Science advances · 2026Article
- Article
- Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway.eLife · 2026Article
- Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.eLife · 2026Article
- Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation.Nature neuroscience · 2026Article
- Perception and neural representation of intermittent odor stimuli in mice.Nature communications · 2026Article
- Temporal sequence geometry enables odor recognition and generalization.bioRxiv : the preprint server for biology · 2026Article
- Mouse olfactory system acts as anemo-detector and anemo-discriminator.Science advances · 2025Article
- Decoding olfactory bulb output: A behavioral assessment of rate, synchrony, and respiratory phase coding.iScience · 2025Article
- Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.Chemical senses · 2025Article
- Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior.Nature communications · 2025Article
- Olfactory bulb tracks breathing rhythms and place in freely behaving mice.bioRxiv : the preprint server for biology · 2024Article
- How do mammals convert dynamic odor information into neural maps for landscape navigation?PLoS biology · 2024Article
- Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.bioRxiv : the preprint server for biology · 2024Article
- Wireless monitoring of respiration with EEG reveals relationships between respiration, behavior, and brain activity in freely moving mice.Journal of neurophysiology · 2024Article
- Simultaneous recording of ultrasonic vocalizations and sniffing from socially interacting individual rats using a miniature microphone.Cell reports methods · 2023Article
- Odor encoding by signals in the olfactory bulb.Journal of neurophysiology · 2023Article
67 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To gain insight into which parameters of neural activity are important in shaping the perception of odors, we combined a behavioral measure of odor perception with optical imaging of odor representations at the level of receptor neuron input to the rat olfactory bulb. Instead of the typical test of an animal's ability to discriminate two familiar odorants by exhibiting an operant response, we used a spontaneously expressed response to a novel odorant-exploratory sniffing-as a measure of odor perception. This assay allowed us to measure the speed with which rats perform spontaneous odor discriminations. With this paradigm, rats discriminated and began responding to a novel odorant in as little as 140 ms. This time is comparable to that measured in earlier studies using operant behavioral readouts after extensive training. In a subset of these trials, we simultaneously imaged receptor neuron input to the dorsal olfactory bulb with near-millisecond temporal resolution as the animal sampled and then responded to the novel odorant. The imaging data revealed that the bulk of the discrimination time can be attributed to the peripheral events underlying odorant detection: receptor input arrives at the olfactory bulb 100-150 ms after inhalation begins, leaving only 50-100 ms for central processing and response initiation. In most trials, odor discrimination had occurred even before the initial barrage of receptor neuron firing had ceased and before spatial maps of activity across glomeruli had fully developed. These results suggest a coding strategy in which the earliest-activated glomeruli play a major role in the initial perception of odor quality, and place constraints on coding and processing schemes based on simple changes in spike rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.