ArticleJournal of clinical biochemistry and nutrition2007
Changes in lymphocyte phenotypes and cytokine production by surgical stress in a rat small intestinal resection model.
Article in Journal of clinical biochemistry and nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Does Massive Bowel Resection in Newborns Affect Further Immunity in Children?Children (Basel, Switzerland) · 2024Article
- The Relationship Between Knowledge, Attitude, Practice, and Fall Prevention for Childhood in Shanghai, China.Frontiers in public health · 2022Article
- The Preventive Role ofJournal of veterinary research · 2021Article
- Host-Gut Microbiota Crosstalk in Intestinal Adaptation.Cellular and molecular gastroenterology and hepatology · 2018Review
- Qihuang decoction promotes the recovery of intestinal immune barrier dysfunction after gastrectomy in rats.American journal of translational research · 2018Article
- Physical properties of root crops treated with novel softening technology capable of retaining the shape, color, and nutritional value of foods.Dysphagia · 2015Article
- Effects of caloric intake on intestinal mucosal morphology and immune cells in rats treated with 5-Fluorouracil.Journal of clinical biochemistry and nutrition · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small intestinal resection rats are used widely as a malabsorption model, but the immunological changes are unclear. We examined the changes in systemic and mucosal immune status after a small intestinal resection in rats with a controlled nutritional status. Rats had 60% of their small intestine removed. At 5 days after the surgery, spleen cells and intraepithelial lymphocytes (IEL) were isolated. The phenotypes of spleen cells and IEL, the production patterns of Th1 and Th2 cytokines, and the proinflammatory cytokine levels in the plasma were measured. CD4+ T cells in the blood and spleen were significantly decreased in the Resection group (p<0.05). In contrast, IEL subpopulations were not different between the two groups. Interferon-gamma production from the spleen cells was significantly decreased in the Resection group (p<0.05). Interleukin (IL)-4 production was not different between the two groups. Plasma IL-6 concentrations were significantly elevated in the Resection group 6 h after surgery (p<0.05). In conclusions, small intestinal resection in rats suppressed systemic immunity, and this model is useful as a surgical stress model.
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