ArticlePloS one2008
Reconstruction of cell lineage trees in mice.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Applications of Single-Cell DNA Sequencing.Annual review of genomics and human genetics · 2021Review
- Deciphering neural heterogeneity through cell lineage tracing.Cellular and molecular life sciences : CMLS · 2021Review
- Clonal tracking using embedded viral barcoding and high-throughput sequencing.Nature protocols · 2020Article
- High-throughput dense reconstruction of cell lineages.Open biology · 2019Article
- Novel Technological Advances in Functional Connectomics inJournal of developmental biology · 2019Review
- Maps of variability in cell lineage trees.PLoS computational biology · 2019Article
- Quantitative Analysis of Synthetic Cell Lineage Tracing Using Nuclease Barcoding.ACS synthetic biology · 2017Article
- Article
- A generic, cost-effective, and scalable cell lineage analysis platform.Genome research · 2016Article
- Accuracy of Answers to Cell Lineage Questions Depends on Single-Cell Genomics Data Quality and Quantity.PLoS computational biology · 2016Article
- Lessons from mouse chimaera experiments with a reiterated transgene marker: revised marker criteria and a review of chimaera markers.Transgenic research · 2015Article
- Using tumour phylogenetics to identify the roots of metastasis in humans.Nature reviews. Clinical oncology · 2015Review
- Genome sequencing of normal cells reveals developmental lineages and mutational processes.Nature · 2014Article
- Lineage grammars: describing, simulating and analyzing population dynamics.BMC bioinformatics · 2014Article
- Determinative developmental cell lineages are robust to cell deaths.PLoS genetics · 2014Article
- Hypermutable DNA chronicles the evolution of human colon cancer.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Single-cell sequencing-based technologies will revolutionize whole-organism science.Nature reviews. Genetics · 2013Review
- Moderate-intensity treadmill running promotes expansion of the satellite cell pool in young and old mice.The FEBS journal · 2013Article
- Article
- Comparing algorithms that reconstruct cell lineage trees utilizing information on microsatellite mutations.PLoS computational biology · 2013Article
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15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cell lineage tree of a multicellular organism represents its history of cell divisions from the very first cell, the zygote. A new method for high-resolution reconstruction of parts of such cell lineage trees was recently developed based on phylogenetic analysis of somatic mutations accumulated during normal development of an organism. In this study we apply this method in mice to reconstruct the lineage trees of distinct cell types. We address for the first time basic questions in developmental biology of higher organisms, namely what is the correlation between the lineage relation among cells and their (1) function, (2) physical proximity and (3) anatomical proximity. We analyzed B-cells, kidney-, mesenchymal- and hematopoietic-stem cells, as well as satellite cells, which are adult skeletal muscle stem cells isolated from their niche on the muscle fibers (myofibers) from various skeletal muscles. Our results demonstrate that all analyzed cell types are intermingled in the lineage tree, indicating that none of these cell types are single exclusive clones. We also show a significant correlation between the physical proximity of satellite cells within muscles and their lineage. Furthermore, we show that satellite cells obtained from a single myofiber are significantly clustered in the lineage tree, reflecting their common developmental origin. Lineage analysis based on somatic mutations enables performing high resolution reconstruction of lineage trees in mice and humans, which can provide fundamental insights to many aspects of their development and tissue maintenance.
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