Trial reportEuropean journal of clinical nutrition2009
Effects of the 'live high-train low' method on prooxidant/antioxidant balance on elite athletes.
Trial report in European journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Trial
- Effects of 12-Week Endurance Training at Natural Low Altitude on the Blood Redox Homeostasis of Professional Adolescent Athletes: A Quasi-Experimental Field Trial.Oxidative medicine and cellular longevity · 2016Trial
- Prooxidant/Antioxidant Balance in Hypoxia: A Cross-Over Study on Normobaric vs. Hypobaric "Live High-Train Low".PloS one · 2015Trial
- Dietary nitrate supplementation very slightly mitigates the oxidative stress induced by high-intensity training performed in normobaric hypoxia.Biology of sport · 2025Article
- Redox status biomarkers in the fast-twitch extensor digitorum longus resulting from the hypoxic exercise.Nagoya journal of medical science · 2022Article
- Acute Exhaustive Exercise under Normoxic and Normobaric Hypoxic Conditions Differentially Regulates Angiogenic Biomarkers in Humans.Medicina (Kaunas, Lithuania) · 2021Article
- Dietary Adjustments to Altitude Training in Elite Endurance Athletes; Impact of a Randomized Clinical Trial With Antioxidant-Rich Foods.Frontiers in sports and active living · 2020Article
- Nutrition and Altitude: Strategies to Enhance Adaptation, Improve Performance and Maintain Health: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2019Review
- Blood Biomarker Profiling and Monitoring for High-Performance Physiology and Nutrition: Current Perspectives, Limitations and Recommendations.Sports medicine (Auckland, N.Z.) · 2019Review
- Hypoxia-Induced Oxidative Stress Modulation with Physical Activity.Frontiers in physiology · 2017Review
- The blood antioxidant defence capacity during intermittent hypoxic training in elite swimmers.Biology of sport · 2016Article
- Dietary Recommendations for Cyclists during Altitude Training.Nutrients · 2016Review
- Alterations in redox homeostasis in the elite endurance athlete.Sports medicine (Auckland, N.Z.) · 2015Article
- Can clinicians and scientists explain and prevent unexplained underperformance syndrome in elite athletes: an interdisciplinary perspective and 2016 update.BMJ open sport & exercise medicine · 2015Article
- Vitamin C supplementation does not improve hypoxia-induced erythropoiesis.High altitude medicine & biology · 2012Article
- The effect of exercise-induced hypoxemia on blood redox status in well-trained rowers.European journal of applied physiology · 2012Article
- Living at high altitude in combination with sea-level sprint training increases hematological parameters but does not improve performance in rats.European journal of applied physiology · 2011Article
- Antioxidant status of elite athletes remains impaired 2 weeks after a simulated altitude training camp.European journal of nutrition · 2010Article
- Thirteen days of "live high-train low" does not affect prooxidant/antioxidant balance in elite swimmers.European journal of applied physiology · 2009Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesWe previously demonstrated that acute exposure to hypoxia (3 h at 3000 m) increased oxidative stress markers. Thus, by using the 'living high-training low' (LHTL) method, we further hypothesized that intermittent hypoxia associated with endurance training alters the prooxidant/antioxidant balance. SUBJECTS/
methodsTwelve elite athletes from the Athletic French Federation were subjected to 18-day endurance training. They were divided into two groups: one group (control group) trained at 1200 m and lived in hypoxia (2500-3000 m simulated altitude) and the second group trained and lived at 1200 m. The subjects performed an acute hypoxic test (10 min at 4800 m) before and immediately after the training. Plasma levels of advanced oxidation protein products (AOPP), malondialdehydes (MDA), ferric-reducing antioxidant power (FRAP), lipid-soluble antioxidants normalized for triacylglycerols, and cholesterol and retinol were measured before and after the 4800 m tests.
resultsAfter the training, MDA and AOPP concentrations were decreased in response to the 4800 m test only for the control group. Eighteen days of LHTL induced a significant decrease of all antioxidant markers (FRAP, P=0.01; alpha-tocopherol, P=0.04; beta-carotene, P=0.01 and lycopene, P=0.02) for the runners. This imbalance between antioxidant and prooxidant might result from insufficient intakes in vitamins A and E.
conclusionsThe LHTL model characterized by the association of aerobic exercises and intermittent resting hypoxia exposures decreased the antioxidant status whereas the normoxic endurance training induced preconditioning mechanisms in response to the 4800 m test.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.