ArticleBiological research for nursing2008
A focused microarray to study human mitochondrial and nuclear gene expression.
Article in Biological research for nursing, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Mitochondrial and Oxidative Impacts of Short and Long-term Administration of HAART on HIV Patients.Current clinical pharmacology · 2020Article
- Fatigue-related gene networks identified in CD14+ cells isolated from HIV-infected patients: part II: statistical analysis.Biological research for nursing · 2013Article
- Fatigue-related gene networks identified in CD(14)+ cells isolated from HIV-infected patients: part I: research findings.Biological research for nursing · 2013Article
- HIV infection and antiretroviral therapy have divergent effects on mitochondria in adipose tissue.The Journal of infectious diseases · 2012Article
- The Mitoscriptome in Aging and Disease.Aging and disease · 2011Article
- Rat mitochondrion-neuron focused microarray (rMNChip) and bioinformatics tools for rapid identification of differential pathways in brain tissues.International journal of biological sciences · 2011Article
- Genopal™: a novel hollow fibre array for focused microarray analysis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2010Article
- Predictive role of mitochondrial genome in the stress resistance of insects and nematodes.Bioinformation · 2010Article
- Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury.Molecular medicine (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
A focused microarray (huMITOchip) was developed to study alterations of human mitochondrial and nuclear gene expression in health and disease. The huMITOchip contains 4,774 probe sets identical to the Affymetrix U 133 plus 2.0 chip covering genes affecting mitochondrial, lipid, cytokine, apoptosis, and muscle function transcripts. Unlike other gene chips, the huMITOchip has 51 probe sets that interrogate 37 genes of the mitochondrial genome. The human mitochondrial gene chip was validated against the Affymetrix U133 plus 2.0 array using an in vitro system of CCL136 muscle cell line stimulated with or without interferon gamma (IFN-gamma). The 37 genes from the mtDNA demonstrated absolute gene expression levels ranging from 0.1 to 3,182. The comparison of the two gene chips yielded an excellent Pearson's correlation coefficient (r = 0.98). At least 17 probe sets were differentially expressed in response to IFN-gamma on both chips, with a high degree of concordance. This is the first report on the development of a focused oligonucleotide microarray containing genes of the mitochondrial genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.