ArticleCellular microbiology2008
Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection.
Article in Cellular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
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- Solute carrier protein family 11 member 1 (Slc11a1) activation efficiently inhibitsJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2017Article
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- Genetic determinants in the development of sensitization to environmental allergens in early childhood.Immunity, inflammation and disease · 2014Article
- Salmonellae PhoPQ regulation of the outer membrane to resist innate immunity.Current opinion in microbiology · 2014Review
- Salmonella enterica causes more severe inflammatory disease in C57/BL6 Nramp1G169 mice than Sv129S6 mice.Veterinary pathology · 2013Article
- Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells.Nature · 2013Article
- Identification and functional characterization of Leishmania donovani secretory peroxidase: delineating its role in NRAMP1 regulation.PloS one · 2013Article
- The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells.Immunity · 2012Article
- Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development.PLoS pathogens · 2012Article
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- The intestinal microbiota plays a role in Salmonella-induced colitis independent of pathogen colonization.PloS one · 2011Article
- Quantitative PCR-based competitive index for high-throughput screening of Salmonella virulence factors.Infection and immunity · 2011Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
Host resistance against Salmonella enterica serovar Typhimurium (S. Typhimurium) is mediated by natural resistance-associated macrophage protein 1 (Nramp1/Slc11a1). Nramp1 is critical to host defence, as mice lacking Nramp1 fail to control bacterial replication and succumb to low doses of S. Typhimurium. Despite this crucial role, the mechanisms underlying Nramp1's protective effects are unclear. Dendritic cells (DCs) that sample the intestinal lumen are among the first cells encountered by S. Typhimurium following oral infection and act as a conduit for S. Typhimurium to cross the intestinal epithelial barrier. We report that DCs, including intestinal, splenic and bone marrow-derived DCs (BMDCs), express Nramp1 protein. In the small intestine, Nramp1 expression is greater in a subset of DCs (CD11c(+)CD103(-)) characterized by the elevated expression of pro-inflammatory cytokines in response to bacterial products. While Nramp1 expression did not affect S. Typhimurium replication in BMDCs, infected Nramp1+/+ BMDCs and intestinal CD11c(+)CD103(-) DCs secreted more inflammatory cytokines (IL-6, IL-12 and TNF-alpha) than Nramp1-/-, suggesting that Nramp1 expression may promote a more rapid inflammatory response following infection. Collectively, these findings reveal a new role for DCs and Nramp1 in modulating the host inflammatory response to S. Typhimurium.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.