Evidence map›Paper›PMID 18397269›Full record

ArticleImmunology2008

Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis.

Han-A Kim, So-Hee Kim, Hyun-Mi Ko, Jung-Hwa Choi, Kyoung-Jin Kim, Sin-Hye Oh, Kyoung-Oh Cho, Il-Whan Choi, Suhn-Young Im

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Dissecting the Mechanism of IntracellularFrontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Han-A KimDepartment of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, Korea. kha1009@hanmail.net
So-Hee Kim
Hyun-Mi Ko
Jung-Hwa Choi
Kyoung-Jin Kim
Sin-Hye Oh
Kyoung-Oh Cho
Il-Whan Choi
Suhn-Young Im
Chonnam National University · KRInje University · KRJeonbuk National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet-activating factor (PAF) has been demonstrated to augment resistance against Candida albicans infection. In this study, the role of nitric oxide (NO) in PAF-induced resistance in the kidneys was investigated. Pretreatment of the C. albicans-infected mice with PAF resulted in strong expression of messenger RNA (mRNA) and the protein synthesis of inducible nitric oxide synthase (iNOS). These PAF effects were inhibited to a significant degree by pretreatment with the nuclear factor-kappaB inhibitor, pyrrolidinedithiocarbamate. Pretreatment with PAF protected the mice from death caused by C. albicans infection and reduced the growth of fungus in the kidneys. The protective activity of PAF was abrogated by pretreatment with the iNOS inhibitor, aminoguanidine, and in the iNOS(-/-) mice. The PAF markedly increased the infiltration of neutrophils, but not macrophages, and also enhanced the mRNA expression levels of the CXC chemokine, keratinocyte-derived chemokine, in C. albicans-infected kidneys. These effects of PAF were attenuated in the aminoguanidine-treated mice and the iNOS(-/-) mice. These data show that NO plays an important role in PAF-induced protection against C. albicans.

Indexed as

AnimalsCandida albicansCandidiasisFemaleGuanidinesKidneyMiceMice, Inbred C57BLMice, KnockoutNeutrophil InfiltrationNeutrophilsNF-kappa BNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIPlatelet Activating FactorGuanidinesNF-kappa BNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIpimagedinePlatelet Activating FactorRNA, Messenger

Identifiers

PMID18397269
PMCPMC2440837
OpenAlexW1973448245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.