ArticleExperimental parasitology2008
Counter-regulatory anti-parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice.
Article in Experimental parasitology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Experimental evolution of Plasmodium yoelii in single and helminth-coinfected mice.Malaria journal · 2025Article
- Efficiency of anthelmintic treatment and its effect on microparasite dynamics in wildInternational journal for parasitology. Parasites and wildlife · 2025Article
- PriorFrontiers in veterinary science · 2024Article
- Infection with soil-transmitted helminths and their impact on coinfections.Frontiers in parasitology · 2023Review
- Effect of Brugia pahangi co-infection with Plasmodium berghei ANKA in gerbils (Meriones unguiculatus).Parasitology research · 2020Article
- Infection against infection: parasite antagonism against parasites, viruses and bacteria.Infectious diseases of poverty · 2019Review
- Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.Frontiers in cellular and infection microbiology · 2017Article
- Malaria endemicity and co-infection with tissue-dwelling parasites in Sub-Saharan Africa: a review.Infectious diseases of poverty · 2015Review
- IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.PLoS pathogens · 2015Article
- Helminth parasites alter protection against Plasmodium infection.BioMed research international · 2014Review
- Immune modulation and modulators in Heligmosomoides polygyrus infection.Experimental parasitology · 2012Review
- Interactions between worms and malaria: good worms or bad worms?Malaria journal · 2011Review
- Helminth infection impairs the immunogenicity of a Plasmodium falciparum DNA vaccine, but not irradiated sporozoites, in mice.Vaccine · 2010Article
- Gastrointestinal nematode infection exacerbates malaria-induced liver pathology.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis.Infection and immunity · 2008Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Malaria and helminth infections are two of the most prevalent parasitic diseases globally. While concomitant infection is common, mechanisms contributing to altered disease outcomes during co-infection remain poorly defined. We have previously reported exacerbation of normally non-lethal Plasmodium yoelii malaria in BALB/c mice chronically infected with the intestinal trematode Echinostoma caproni. The goal of the present studies was to determine the effect of helminth infection on IFN-gamma and other key cytokines during malaria co-infection in the P. yoelii-E. caproni and P. yoelii-Heligmosomoides polygyrus model systems. Polyclonally stimulated spleen cells from both E. caproni- and H. polygyrus-infected mice produced significantly lower amounts of IFN-gamma during P. yoelii co-infection than malaria-only infected mice. Furthermore, the magnitude of IFN-gamma suppression was correlated with the relative amounts of IL-4 induced by these helminths (E. caproni=low; H. polygyrus=high), but not IL-10. Concurrent malaria infection also suppressed helminth-associated IL-4 responses, indicating that immunologic counter-regulation occurs during co-infection with malaria and intestinal helminths.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.