ArticleBrain, behavior, and immunity2008
Symptom severity predicts degree of T cell activation in adult women following childhood maltreatment.
Article in Brain, behavior, and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Altered gene expression and PTSD symptom dimensions in World Trade Center responders.Molecular psychiatry · 2022Pooled it
- Pooled it
- Psychological Scars and Physical Consequences: Linking PTSD to Cardiovascular Health.Journal of cardiovascular translational research · 2026Review
- Selective inflammatory propensities in adopted adolescents institutionalized as infants.Psychoneuroendocrinology · 2021Article
- IL-6 and hsCRP in Somatic Symptom Disorders and related disorders.Brain, behavior, & immunity - health · 2020Article
- Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.Neurotoxicity research · 2020Article
- Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype.Molecular medicine (Cambridge, Mass.) · 2020Article
- Childhood adversity and mechanistic links to hypertension risk in adulthood.British journal of pharmacology · 2019Review
- A peripheral immune response to remembering trauma contributes to the maintenance of fear memory in mice.Psychoneuroendocrinology · 2018Article
- Catecholamines in Post-traumatic Stress Disorder: A Systematic Review and Meta-Analysis.Frontiers in molecular neuroscience · 2018Article
- Gender-based violence and trauma in marginalized populations of women: Role of biological embedding and toxic stress.Health care for women international · 2018Article
- Biological embedding of childhood adversity: from physiological mechanisms to clinical implications.BMC medicine · 2017Review
- Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Review: Puberty as a time of remodeling the adult response to ovarian hormones.The Journal of steroid biochemistry and molecular biology · 2016Review
- The Anti-Inflammatory Effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder (PTSD).PloS one · 2016Article
- INTIMATE PARTNER VIOLENCE IS ASSOCIATED WITH INCREASED CD4Pathogens & immunity · 2016Article
- An Act of Balance Between Adaptive and Maladaptive Immunity in Depression: a Role for T Lymphocytes.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Review
- Autonomic and inflammatory consequences of posttraumatic stress disorder and the link to cardiovascular disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- Annual research review: The neuroinflammation hypothesis for stress and psychopathology in children--developmental psychoneuroimmunology.Journal of child psychology and psychiatry, and allied disciplines · 2014Article
- Immune status influences fear and anxiety responses in mice after acute stress exposure.Brain, behavior, and immunity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Although depression is often associated with a reduction in cellular immune responses, other types of emotional disturbance and psychopathology can activate certain aspects of immunity. Activation markers on T cells, in particular, have been found to be elevated in post-traumatic stress states. However, little is known about the relationship between the severity of PTSD symptoms and the degree of change in T cell phenotypes, or about the potential role of neuroendocrine factors in mediating the association. Twenty-four women with a history of sexual trauma during childhood, including 11 who met diagnostic criteria for PTSD, were compared to 12 age-matched, healthy women without a history of maltreatment. The women provided fasted blood samples for enumeration of cell subsets by immunofluorescence and 24-h urine samples for analysis of catecholamine and cortisol levels. The percent of T cells expressing CD45RA, an early activation marker, was higher in the PTSD diagnosed women, and the levels correlated positively with intrusive symptoms and negatively with avoidant symptoms. These alterations in cell surface markers did not appear to be mediated by norepinephrine (NE) or cortisol, making them a distinctive and independent biomarker of arousal and disturbance in PTSD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.