Trial reportWorld journal of gastroenterology2008
Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: a randomized controlled study.
Trial report in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Extracorporeal therapies for post-liver transplant recipient: The road less traveled.World journal of transplantation · 2025Review
- Comparison of Open Albumin Dialysis (OPAL) With Prometheus Fractionated Plasma Separation and Adsorption (FPSA) and Standard Medical Treatment for Acute-On-Chronic Liver Failure.Artificial organs · 2025Article
- Extracorporeal liver support and liver transplantation for acute-on-chronic liver failure.Liver international : official journal of the International Association for the Study of the Liver · 2025Review
- Safety and efficacy of Single-Pass Albumin Dialysis (SPAD), Prometheus, and Molecular Adsorbent Recycling System (MARS) liver haemodialysis vs. Standard Medical Therapy (SMT): meta-analysis and systematic review.Przeglad gastroenterologiczny · 2024Review
- Liver replacement therapy with extracorporeal blood purification techniques current knowledge and future directions.World journal of clinical cases · 2023Review
- Extracorporeal Liver Support: An Updated Review of Mechanisms and Current Literature.Journal of community hospital internal medicine perspectives · 2022Review
- Acute kidney injury spectrum in patients with chronic liver disease: Where do we stand?World journal of gastroenterology · 2019Review
- An evaluation of the usefulness of extracorporeal liver support techniques in patients with severe liver dysfunction.Archives of medical science : AMS · 2019Article
- Artificial liver support systems: what is new over the last decade?Annals of intensive care · 2018Review
- A comparison among three different apheretic techniques for treatment of hyperbilirubinemia.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2018Article
- [Extracorporeal therapies in hepatic diseases].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Review
- Current state of knowledge of hepatic encephalopathy (part IV): Management of Hepatic Encephalopathy by liver support systems.Metabolic brain disease · 2017Review
- Role of human albumin in the management of complications of liver cirrhosis.Journal of clinical and experimental hepatology · 2014Review
- The role of molecular adsorbent recirculating system dialysis for extracorporeal liver support in children.Pediatric nephrology (Berlin, Germany) · 2013Review
- Modifying three-dimensional scaffolds from novel nanocomposite materials using dissolvable porogen particles for use in liver tissue engineering.Journal of biomaterials applications · 2013Article
- Liver support systems: will they ever reach prime time?Current gastroenterology reports · 2013Review
- The end-organ impairment in liver cirrhosis: appointments for critical care.Critical care research and practice · 2012Article
- Extracorporeal liver support.OrganogenesisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate treatment safety and hemodynamic changes during a single 6-h treatment with the Prometheus liver assist system in a randomized, controlled study.
methodsTwenty-four patients were randomized to either the study group or to one of two control groups: Fractionated Plasma Separation Adsorption and Dialysis, Prometheus system (Study group; n = 8); Molecular Adsorbent Recirculation System (MARS) (Control group 1, n = 8); or hemodialysis (Control group 2; n = 8). All patients included in the study had decompensated cirrhosis at the time of the inclusion into the study. Circulatory changes were monitored with a Swan-Ganz catheter and bilirubin and creatinine were monitored as measures of protein-bound and water-soluble toxins.
resultsSystemic hemodynamics did not differ between treatment and control groups apart from an increase in arterial pressure in the MARS group (P = 0.008). No adverse effects were observed in any of the groups. Creatinine levels significantly decreased in the MARS group (P = 0.03) and hemodialysis group (P = 0.04). Platelet count deceased in the Prometheus group (P = 0.04).
conclusionExtra-corporal liver support with Prometheus is proven to be safe in patients with endstage liver disease but does not exert the beneficial effects on arterial pressure as seen in the MARS group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.