ReviewWorld journal of gastroenterology2008
Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy.
Review in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03594708 (Impact of Immunonutrition Supplementation Combining Fermentable Fiber, Omega-3 Fatty Acids, Vitamin D, Vitamin E, and Zinc on Intestinal Inflammation, Gut Microbial Activity, and Severity of Symptoms in Ulcerative Colitis Patients), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Immunonutrition Supplementation Combining Fermentable Fiber, Omega-3 Fatty Acids, Vitamin D, Vitamin E, and Zinc on Intestinal Inflammation, Gut Microbial Activity, and Severity of Symptoms in Ulcerative Colitis Patients
Who cites it
28 citing papers in PubMed, 101 citations in OpenAlex.
- Physical Activity and Education in the Care of IBD: The Role of the Physiotherapist-A Narrative Review.Journal of clinical medicine · 2025Review
- Reactive Oxygen Species-Responsive Polymeric Chloroquine Nanogel for Targeted Oral Therapy of Ulcerative Colitis.ACS applied materials & interfaces · 2025Article
- Investigation of Some Long Noncoding RNAs (LncRNAs) in Pediatric Inflammatory Bowel Disease (IBD): An Iranian Study.Biochemistry research international · 2025Article
- Ginsenoside Rg1 attenuates dextran sodium sulfate-induced ulcerative colitis in mice.Physiological research · 2023Article
- Anti-inflammatory and Immunomodulatory Potency of Selenium-Enriched Probiotic Mutants in Mice with Induced Ulcerative Colitis.Biological trace element research · 2023Article
- Role of CD34 in inflammatory bowel disease.Frontiers in physiology · 2023Review
- IL-1 and CD40/CD40L platelet complex: elements of induction of Crohn's disease and new therapeutic targets.Archives of pharmacal research · 2021Review
- High-Fat Diet Promotes DSS-Induced Ulcerative Colitis by Downregulated FXR Expression through the TGFB Pathway.BioMed research international · 2020Article
- Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography.Tomography (Ann Arbor, Mich.) · 2018Article
- Anti-inflammatory effect of a novel locally acting APurinergic signalling · 2018Article
- Signalling mechanisms in PAF-induced intestinal failure.Scientific reports · 2017Article
- Recent Trends in Pharmacological Activity of Alkaloids in Animal Colitis: Potential Use for Inflammatory Bowel Disease.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- The Immunological Basis of Inflammatory Bowel Disease.Gastroenterology research and practice · 2016Review
- Umbilical cord mesenchymal stem cells modulate dextran sulfate sodium induced acute colitis in immunodeficient mice.Stem cell research & therapy · 2015Article
- Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments.Mediators of inflammation · 2015Review
- Hydrolysate from eggshell membrane ameliorates intestinal inflammation in mice.International journal of molecular sciences · 2014Article
- Endometrial regenerative cells as a novel cell therapy attenuate experimental colitis in mice.Journal of translational medicine · 2014Article
- Immunologic and genetic markers in patients with idiopathic ocular inflammation and a family history of inflammatory bowel disease.American journal of ophthalmology · 2012Article
- Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression.Journal of leukocyte biology · 2011Article
- Effects of feeding potato pulp on cholesterol metabolism and its association with cecal conditions in rats.Plant foods for human nutrition (Dordrecht, Netherlands) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Al though the aetiology of inflammatory bowel disease (IBD) remains unknown, the pathogenesis is gradually being unravelled, seeming to be the result of a combination of environmental, genetic, and immunological factors in which an uncontrolled immune response within the intestinal lumen leads to inflammation in genetically predisposed individuals. Multifactorial evidence suggests that a defect of innate immune response to microbial agents is involved in IBD. This editorial outlines the immunopathogenesis of IBD and their current and future therapy. We present IBD as a result of dysregulated mucosal response in the intestinal wall facilitated by defects in epithelial barrier function and the mucosal immune system with excessive production of cytokines growth factors, adhesion molecules, and reactive oxygen metabolites, resulting in tissue injury. Established and evolving therapies are discussed in the second part of this editorial and at the end of this section we review new therapies to modulate the immune system in patients with IBD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.