Evidence map›Paper›PMID 18395317›Full record

ReviewBiological psychology2008

Neural phenotypes of common and rare genetic variants.

Carrie E Bearden, David C Glahn, Agatha D Lee, Ming-Chang Chiang, Theo G M van Erp, Tyrone D Cannon, Allan L Reiss, Arthur W Toga, Paul M Thompson

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biological psychology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Genetic architecture of declarative memory: implications for complex illnesses.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2012
    Review
  3. Article
  4. Review
  5. The future of genetics in psychology and psychiatry: microarrays, genome-wide association, and non-coding RNA.Journal of child psychology and psychiatry, and allied disciplines · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Carrie E BeardenDepartment of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States. cbearden@mednet.ucla.edu
David C Glahn
Agatha D Lee
Ming-Chang Chiang
Theo G M van Erp
Tyrone D Cannon
Allan L Reiss
Arthur W Toga
Paul M Thompson
University of California, Los Angeles · USStanford University · USThe University of Texas Health Science Center at San Antonio · US

Funding

UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI APOSTOLOVA, LIANA G · 1999 to 2014
$25.9M
Center for Computational Biology (RMI)U54RR021813 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TOGA, ARTHUR W · 2004 to 2010
$25.3M
Genetic influences on the brain: A twin imaging studyR01HD050735 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI WRIGHT, MARGARET JANE · 2007 to 2011
$2.6M
COGNITIVE PHENOTYPING:NEUROPSYCHIATRIC THERAPEUTICS(RMI)P20RR020750 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2004 to 2006
$1.8M
DIGITAL REPRESENTATION AND VISUALIZATION OF HUMAN BRAINR01LM005639 · NLM · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TOGA, ARTHUR W · 1995 to 2005
$1.8M
Response Inhibition and Dopamine Neurotransmission (RI) (4 of 8)RL1DA024853 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2007 to 2011
$1.7M
Identification of endophenotypes for bipolar disorderK23MH074644 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E · 2005 to 2009
$808k
Consortium for Neuropsychiatric Phenomics-Coordinating CenterUL1RR024911 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2007 to 2007
$380k
Novel PDEs for Cortical Mapping and Analysis in DiseaseR21RR019771 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2003 to 2004
$351k
NCRR NIH HHS P20 RR020750NCRR NIH HHS P20RR020750NCRR NIH HHS R21 RR019771NCRR NIH HHS RR019771NCRR NIH HHS U54 RR021813NCRR NIH HHS UL1 RR024911NCRR NIH HHS UL1RR024911NIA NIH HHS AG016570NIA NIH HHS P50 AG016570NIBIB NIH HHS EB01651NICHD NIH HHS HD050735NICHD NIH HHS R01 HD050735NIDA NIH HHS RL1 DA024853NIMH NIH HHS K23 MH074644NINDS NIH HHS NS049194NLM NIH HHS LM05639NLM NIH HHS R01 LM005639
6 · The paper itself

Abstract

Neuroimaging methods offer a powerful way to bridge the gaps between genes, neurobiology and behavior. Such investigations may be further empowered by complementary strategies involving chromosomal abnormalities associated with particular neurobehavioral phenotypes, which can help to localize causative genes and better understand the genetics of complex traits in the general population. Here we review the evidence from studies using these convergent approaches to investigate genetic influences on brain structure: (1) studies of common genetic variations associated with particular neuroanatomic phenotypes, and (2) studies of possible 'genetic subtypes' of neuropsychiatric disorders with very high penetrance, with a focus on neuroimaging studies using novel computational brain mapping algorithms. Finally, we discuss the contribution of behavioral neurogenetics research to our understanding of the genetic basis of neuropsychiatric disorders in the broader population.

Indexed as

AnimalsChromosome AberrationsGenetic VariationHumansMutationNervous SystemNervous System DiseasesPhenotype

Identifiers

PMID18395317
PMCPMC2535822
OpenAlexW2007797346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.