ArticleDevelopmental biology2008
A novel mRNA 3' untranslated region translational control sequence regulates Xenopus Wee1 mRNA translation.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
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- Translational Control ofCells · 2020Review
- Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function.Clinical epigenetics · 2019Article
- Functional Integration of mRNA Translational Control Programs.Biomolecules · 2015Review
- Article
- Zar1 represses translation in Xenopus oocytes and binds to the TCS in maternal mRNAs with different characteristics than Zar2.Biochimica et biophysica acta · 2013Article
- Xenopus laevis zygote arrest 2 (zar2) encodes a zinc finger RNA-binding protein that binds to the translational control sequence in the maternal Wee1 mRNA and regulates translation.Developmental biology · 2012Article
- Biochemical characterization of Pumilio1 and Pumilio2 in Xenopus oocytes.The Journal of biological chemistry · 2011Article
- Developmental timing of mRNA translation--integration of distinct regulatory elements.Molecular reproduction and development · 2010Review
- Enforcing temporal control of maternal mRNA translation during oocyte cell-cycle progression.The EMBO journal · 2010Article
- A novel, noncanonical mechanism of cytoplasmic polyadenylation operates in Drosophila embryogenesis.Genes & development · 2010Article
- Proteasomal activity is required to initiate and to sustain translational activation of messenger RNA encoding the stem-loop-binding protein during meiotic maturation in mice.Biology of reproduction · 2010Article
- Specificity factors in cytoplasmic polyadenylation.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Cell cycle progression during oocyte maturation requires the strict temporal regulation of maternal mRNA translation. The intrinsic basis of this temporal control has not been fully elucidated but appears to involve distinct mRNA 3' UTR regulatory elements. In this study, we identify a novel translational control sequence (TCS) that exerts repression of target mRNAs in immature oocytes of the frog, Xenopus laevis, and can direct early cytoplasmic polyadenylation and translational activation during oocyte maturation. The TCS is functionally distinct from the previously characterized Musashi/polyadenylation response element (PRE) and the cytoplasmic polyadenylation element (CPE). We report that TCS elements exert translational repression in both the Wee1 mRNA 3' UTR and the pericentriolar material-1 (Pcm-1) mRNA 3' UTR in immature oocytes. During oocyte maturation, TCS function directs the early translational activation of the Pcm-1 mRNA. By contrast, we demonstrate that CPE sequences flanking the TCS elements in the Wee1 3' UTR suppress the ability of the TCS to direct early translational activation. Our results indicate that a functional hierarchy exists between these distinct 3' UTR regulatory elements to control the timing of maternal mRNA translational activation during oocyte maturation.
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