ArticleMolecular immunology2008
What does the T-cell receptor recognize when it docks on an MHC-encoded restricting element?
Article in Molecular immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- On the logic of restrictive recognition of peptide by the T-cell antigen receptor.Immunologic research · 2011Article
- Why rethink the structure-function relationships regulating TCR behavior?Current trends in immunology · 2009Article
- The discussion with Jacques Miller: illustrating the limitations of pure empiricism.Immunology and cell biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The postulate is analyzed that single V-gene segments encode recognition of the allele-specific determinants (a) required for the restrictive response of the alphabeta TCR to peptide. The consequence of this is that the positively selected V-domain, Valpha or Vbeta, engages an allele-specific determinant (a) on one subunit or domain of the MHC-encoded restricting element. The entrained V-domain docks on an invariant determinant (i) on the complementing subunit or domain. Consequently, each functional V-domain expresses an anti-a site and an anti-i site, and all subunits or domains of MHC-encoded restricting elements express an a- and i-determinant. The evidence, both biological and structural, discussed here strongly supports this postulate which has far reaching consequences.
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Registered trials
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