ReviewProgress in brain research2008
New tricks for an old slug: the critical role of postsynaptic mechanisms in learning and memory in Aplysia.
Review in Progress in brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Single-neuron analysis of aging-associated changes in learning reveals impairments in transcriptional plasticity.Aging cell · 2024Article
- Repeated stimulation of feeding mechanoafferents inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Fear conditioning in invertebrates.Frontiers in behavioral neuroscience · 2022Review
- Neurotropic and modulatory effects of insulin-like growth factor II in Aplysia.Scientific reports · 2019Article
- Role of nitric oxide in the induction of the behavioral and cellular changes produced by a common aversive stimulus in Aplysia.Behavioural brain research · 2019Article
- Characterization and reversal of Doxorubicin-mediated biphasic activation of ERK and persistent excitability in sensory neurons of Aplysia californica.Scientific reports · 2017Article
- Article
- Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Age-related deficits in synaptic plasticity rescued by activating PKA or PKC in sensory neurons of Aplysia californica.Frontiers in aging neuroscience · 2015Article
- Aging in Sensory and Motor Neurons Results in Learning Failure in Aplysia californica.PloS one · 2015Article
- Susceptibility of memory consolidation during lapses in recall.Nature communications · 2013Article
- Release properties of individual presynaptic boutons expressed during homosynaptic depression and heterosynaptic facilitation of the Aplysia sensorimotor synapse.Frontiers in cellular neuroscience · 2013Article
- Mapping molecular memory: navigating the cellular pathways of learning.Cellular and molecular neurobiology · 2012Review
- Unique ionotropic receptors for D-aspartate are a target for serotonin-induced synaptic plasticity in Aplysia californica.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2012Article
- Dynamic reconfiguration of human brain networks during learning.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The participation of NMDA receptors, PKC, and MAPK in the formation of memory following operant conditioning in Lymnaea.Molecular brain · 2010Article
- Long-lasting synaptic potentiation induced by depolarization under conditions that eliminate detectable Ca2+ signals.Journal of neurophysiology · 2010Article
- Description and validation of a dynamical systems model of presynaptic serotonin function: genetic variation, brain activation and impulsivity.Behavior genetics · 2010Article
- Hormonal modulation of sensorimotor integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- PKC differentially translocates during spaced and massed training in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The marine snail Aplysia has served for more than four decades as an important model system for neurobiological analyses of learning and memory. Until recently, it has been believed that learning and memory in Aplysia were due predominately, if not exclusively, to presynaptic mechanisms. For example, two nonassociative forms of learning exhibited by Aplysia, sensitization and dishabituation of its defensive withdrawal reflex, have been previously ascribed to presynaptic facilitation of the connections between sensory and motor neurons that mediate the reflex. Recent evidence, however, indicates that postsynaptic mechanisms play a far more important role in learning and memory in Aplysia than formerly appreciated. In particular, dishabituation and sensitization depend on a rise in intracellular Ca(2+) in the postsynaptic motor neuron, postsynaptic exocytosis, and modulation of the functional expression of postsynaptic AMPA-type glutamate receptors. In addition, the expression of the persistent presynaptic changes that occur during intermediate- and long-term dishabituation and sensitization appears to require retrograde signals that are triggered by elevated postsynaptic Ca(2+). The model for learning-related synaptic plasticity proposed here for Aplysia is similar to current mammalian models. This similarity suggests that the cellular mechanisms of learning and memory have been highly conserved during evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.