Evidence map›Paper›PMID 18394167›Full record

ArticleWorld journal of surgical oncology2008

The Merendino procedure following preoperative imatinib mesylate for locally advanced gastrointestinal stromal tumor of the esophagogastric junction.

Wilko I Staiger, Ulrich Ronellenfitsch, Georg Kaehler, Hans Ulrich Schildhaus, Antonia Dimitrakopoulou-Strauss, Matthias Hm Schwarzbach, Peter Hohenberger

Open access · goldAbstract readCase Reports
In one paragraph

Article in World journal of surgical oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Neoadjuvant therapy for gastrointestinal stromal tumor.Translational gastroenterology and hepatology · 2018
    Review
  4. Article
  5. Article
  6. Article
  7. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Wilko I StaigerDiv, Surgical Oncology and Thoracic Surgery, Department of Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany. wilko.staiger@chir.ma.uni-heidelberg.de
Ulrich Ronellenfitsch
Georg Kaehler
Hans Ulrich Schildhaus
Antonia Dimitrakopoulou-Strauss
Matthias Hm Schwarzbach
Peter Hohenberger
Heidelberg University · DEGerman Cancer Research Center · DEUniversity Hospital Heidelberg · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastrointestinal stromal tumors (GIST) of the esophagogastric junction might pose a major problem to surgical resection. If locally advanced, extended or multivisceral resection with relevant procedural-specific morbidity and mortality is often necessary. CASE PRESENTATION: We report a case of a patient with a locally advanced GIST of the esophagogastric junction who was treated by transhiatal resection of the lower esophagus and gastric cardia with reconstruction by interposition of segment of the jejunum (Merendino procedure). Prior to resection, downsizing of the tumor had successfully been achieved by treatment with imatinib mesylate for six months. Histological proof of GIST by immunohistochemical expression of c-KIT and/or PDGF alpha Receptor is crucial to allow embarking on this treatment strategy.

conclusionA multimodal approach for an advanced GIST of the esophagogastric junction with preoperative administration of imatinib mesylate could avoid extended resection. The Merendino procedure might be considered as the reconstruction method of choice after resection of GIST at this location.

Indexed as

Antineoplastic AgentsBenzamidesChemotherapy, AdjuvantEsophagogastric JunctionGastrointestinal Stromal TumorsHumansImatinib MesylateMaleMiddle AgedNeoadjuvant TherapyPiperazinesProtein Kinase InhibitorsPyrimidinesAntineoplastic AgentsBenzamidesImatinib MesylatePiperazinesProtein Kinase InhibitorsPyrimidines

Identifiers

PMID18394167
PMCPMC2323006
OpenAlexW2084101574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.