ArticleCell regulation1991
Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes.
Article in Cell regulation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 135 citations in OpenAlex.
- Identifying potential ligand-receptor interactions by integrating LSTM network and the attention mechanism for cell-cell communication prediction.Journal of translational medicine · 2026Article
- Dystroglycan-HSPG interactions provide synaptic plasticity and specificity.Glycobiology · 2024Review
- We need to talk-how muscle stem cells communicate.Frontiers in cell and developmental biology · 2024Review
- The role of integrins in melanoma: a review.International journal of dermatology · 2020Review
- Tumor Cells Develop Defined Cellular Phenotypes After 3D-Bioprinting in Different Bioinks.Cells · 2019Article
- Engineered matrices for skeletal muscle satellite cell engraftment and function.Matrix biology : journal of the International Society for Matrix Biology · 2017Review
- Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.American journal of translational research · 2016Article
- Molecular profiling of ADAM12 and ADAM17 genes in human malignant melanoma.Pathology oncology research : POR · 2013Article
- Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy.Orphanet journal of rare diseases · 2013Article
- Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness.Molecular cancer · 2010Article
- Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets.Expert reviews in molecular medicine · 2010Review
- The role of integrins in cancer and the development of anti-integrin therapeutic agents for cancer therapy.Perspectives in medicinal chemistry · 2008Article
- Formation and properties of hairpin and tetraplex structures of guanine-rich regulatory sequences of muscle-specific genes.Nucleic acids research · 2005Article
- Neurite outgrowth by the alternatively spliced region of human tenascin-C is mediated by neuronal alpha7beta1 integrin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Integrin alpha 7 beta 1 in muscular dystrophy/myopathy of unknown etiology.The American journal of pathology · 2002Article
- A comparison of ocular melanocyte and uveal melanoma cell invasion and the implication of alpha1beta1, alpha4beta1 and alpha6beta1 integrins.The British journal of ophthalmology · 2001Article
- Impaired axonal regeneration in alpha7 integrin-deficient mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow.British journal of cancer · 1999Article
- Neuronal receptors mediating responses to antibodyactivated laminin-1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- The role of laminins in basement membrane function.Journal of anatomy · 1998Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
A novel integrin, alpha 7 beta 1, that specifically binds with high affinity to laminin has been identified on melanoma cells. This complex was purified from both human and murine melanoma cells by laminin-affinity chromatography, and the alpha 7 subunit was recovered after gel electrophoresis. N-terminal amino acid sequence analysis of the alpha 7 subunit from both human and mouse cells verifies that this integrin is distinct from other alpha chains in the beta 1 family, although strikingly similar to the alpha 6 subunit. By using specific proteolytically derived fragments of laminin, it was determined that the alpha 7 beta 1 complex binds selectively to the E8 region, which represents part of the long arm of laminin. In contrast, the receptor failed to bind to the P1 fragment, which contains the intersection of the short arms of laminin. Although the alpha 7 beta 1 complex was commonly expressed in melanoma cells, this integrin was not detected in normal melanocytes, suggesting that alpha 7 expression may be associated with malignant transformation. These results establish the existence of a novel integrin that binds to the E8 domain of laminin and appears to mediate cell adhesion to this ligand.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.