Evidence map›Paper›PMID 18392675›Full record

Trial reportJournal of assisted reproduction and genetics2008

Growth hormone co-treatment within a GnRH agonist long protocol in patients with poor ovarian response: a prospective, randomized, clinical trial.

Tansu Kucuk, Hakan Kozinoglu, Ayten Kaba

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of assisted reproduction and genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02179255 (An Open-Label Randomized Controlled Trial), which is not on this map. Cited by 45 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 9 pooled it
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02179255 phase1 / phase2unknown statusnot on this mapstarted 2014, after this paper: background citation

An Open-Label Randomized Controlled Trial (RCT) of 6 Weeks of Human Growth Hormone (HGH) Prior to Ovulation Induction for In Vitro Fertilization (IVF)

TypeinterventionalSponsorCenter for Human ReproductionRan2014 to 2022Enrolled30ConditionsFemale Infertility Due to Diminished Ovarian ReserveArmsHuman Growth Hormone, Follicle Stimulating Hormone
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 9 syntheses or guidelines pooled it, 116 citations in OpenAlex.

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  5. Growth hormone for in vitro fertilisation (IVF).The Cochrane database of systematic reviews · 2021
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  9. Growth hormone for in vitro fertilization.The Cochrane database of systematic reviews · 2010
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tansu KucukDepartment Obstetrics and Gynaecology, GATA School of Medicine, 06018 Etlik, Ankara, Turkey. tansukucuk@gmail.com
Hakan Kozinoglu
Ayten Kaba
Scientific and Technological Research Council of Turkey · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe efficacy of growth hormone co-stimulation to long luteal GnRHa regimen in poor responders to COH for IVF was assessed.

methodsThis prospective, randomized, clinical trial was performed in a private assisted reproduction center. The study involved 61 patients who responded poorly to high dose gonadotropin treatment in their first cycles in the same center. Study group of 31 patients were given growth hormone co-treatment, daily subcutaneous injection of 4 mg from day 21 of preceding cycle along with GnRHa, until the day of hCG. Control group of 30 patients received the same treatment protocol except the growth hormone cotreatment. Primary end-point of the study was the number of oocytes fertilized whereas the pregnancy rate was the secondary end-point.

resultsPatients' demographic characteristics did not differ significantly between the two groups. 2PNs in growth hormone co-treatment group was significantly higher than the control group (4.4 +/- 1.8 vs 1.5 +/- 0.9, p < 0.001). Although more pregnancies and more clinical pregnancies with fetal heart beat were achieved in growth hormone group (12/31), compared to the control group (6/30), the difference did not reach to statistical significance.

conclusionPoor responder women undergoing repeated assisted reproduction treatment and co-stimulated with GH achieve more oocytes, higher fertilization rate if growth hormone started in the luteal phase of previous cycle, as compared with women of the same status treated with GnRHa long protocol. The study was unable to show that clinical pregnancy rate was increased significantly.

Indexed as

Ovulation InductionAdultDrug Therapy, CombinationFemaleGonadotropin-Releasing HormoneHuman Growth HormoneHumansLongitudinal StudiesOvaryPregnancyProspective StudiesTreatment OutcomeTriptorelin PamoateGonadotropin-Releasing HormoneHuman Growth HormoneTriptorelin Pamoate

Identifiers

PMID18392675
PMCPMC2582075
OpenAlexW2083434409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.