ReviewBritish journal of cancer2008
The role of early life genistein exposures in modifying breast cancer risk.
Review in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.
- Adolescent Dietary Intake and Breast Cancer in Adulthood: A Systematic Review and Meta-analysis.Advances in nutrition (Bethesda, Md.) · 2025Pooled it
- Knowledge and perceptions of familial and genetic risks for breast cancer risk in adolescent girls.Breast cancer research and treatment · 2012Trial
- Biomarkers of dietary exposure are associated with lower risk of breast fibroadenomas in Chinese women.The Journal of nutrition · 2010Trial
- Soy Intake During Childhood and/or Adolescence and Adult Breast Cancer: An Examination of the Early Soy Intake Hypothesis.Nutrients · 2026Review
- Article
- The benefit of vegetarian diets for reducing blood pressure in Taiwan: a historically prospective cohort study.Journal of health, population, and nutrition · 2023Article
- Targeting Breast Cancer Stem Cells Using Naturally Occurring Phytoestrogens.International journal of molecular sciences · 2022Review
- Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations.Carcinogenesis · 2022Article
- Maternal Consumption of a Low-Isoflavone Soy Protein Isolate Diet Accelerates Chemically Induced Hepatic Carcinogenesis in Male Rat Offspring.Nutrients · 2020Article
- Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer.Frontiers in nutrition · 2020Review
- Epigenetic Activation ofNutrients · 2019Article
- Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation.Archives of toxicology · 2018Review
- State of the evidence 2017: an update on the connection between breast cancer and the environment.Environmental health : a global access science source · 2017Review
- The potential health effects of dietary phytoestrogens.British journal of pharmacology · 2017Review
- SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24Stem cell reports · 2017Article
- Lifetime Genistein Intake Increases the Response of Mammary Tumors to Tamoxifen in Rats.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- Botanicals and Their Bioactive Phytochemicals for Women's Health.Pharmacological reviews · 2016Review
- Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies.Oxidative medicine and cellular longevity · 2016Review
- Dietary isoflavones and gastric cancer: A brief review of current studies.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Review
- Advancing research on endocrine disrupting chemicals in breast cancer: Expert panel recommendations.Reproductive toxicology (Elmsford, N.Y.) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Review of the existing literature suggests that consumption of soy foods or an exposure to a soy isoflavone genistein during childhood and adolescence in women, and before puberty onset in animals, reduces later mammary cancer risk. In animal studies, an exposure that is limited to the fetal period or adult life does not appear to have the same protective effect. A meta-analysis of human studies indicates a modest reduction in pre- and postmenopausal risk when dietary intakes are assessed during adult life. These findings concur with emerging evidence indicating that timing may be vitally important in determining the effects of various dietary exposures on the susceptibility to develop breast cancer. In this review, we address the mechanisms that might mediate the effects of an early life exposure to genistein on the mammary gland. The focus is on changes in gene expression, such as those involving BRCA1 and PTEN. It will be debated whether mammary stem cells are the targets of genistein-induced alterations and also whether the alterations are epigenetic. We propose that the effects on mammary gland morphology and signalling pathways induced by pubertal exposure to genistein mimic those induced by the oestrogenic environment of early first pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.