Evidence map›Paper›PMID 18392052›Full record

Trial reportBritish journal of cancer2008

Prevalence of type-specific HPV infection by age and grade of cervical cytology: data from the ARTISTIC trial.

A Sargent, A Bailey, M Almonte, A Turner, C Thomson, J Peto, M Desai, J Mather, S Moss, C Roberts and 2 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 6 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 6 syntheses or guidelines pooled it, 118 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Surgery for cervical intraepithelial neoplasia.The Cochrane database of systematic reviews · 2013
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Surgery for cervical intraepithelial neoplasia.The Cochrane database of systematic reviews · 2010
    Pooled it
  7. Performance and acceptability of self-collected human papillomavirus testing among women living with HIV.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  19. Article
  20. Implementation of primary HPV testing in Japan.Molecular and clinical oncology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

A SargentDivision of Cancer Studies and Imaging, University of Manchester, Hathersage Road, Manchester M13 0JH, UK.
A Bailey
M Almonte
A Turner
C Thomson
J Peto
M Desai
J Mather
S Moss
C Roberts
H C Kitchener
ARTISTIC Study Group
University of Manchester · GBUniversity of London · GBInstitute of Cancer Research · GBRoyal Manchester Children's Hospital · GB

Funding

Department of Health 98/04/64
6 · The paper itself

Abstract

Human papillomavirus (HPV) infection causes cervical cancer and premalignant dysplasia. Type-specific HPV prevalence data provide a basis for assessing the impact of HPV vaccination programmes on cervical cytology. We report high-risk HPV (HR-HPV) type-specific prevalence data in relation to cervical cytology for 24,510 women (age range: 20-64; mean age 40.2 years) recruited into the ARTISTIC trial, which is being conducted within the routine NHS Cervical Screening Programme in Greater Manchester. The most common HR-HPV types were HPV16, 18, 31, 51 and 52, which accounted for 60% of all HR-HPV types detected. There was a marked decline in the prevalence of HR-HPV infection with age, but the proportion due to each HPV type did not vary greatly with age. Multiple infections were common below the age of 30 years but less so between age 30 and 64 years. Catch-up vaccination of this sexually active cohort would be expected to reduce the number of women with moderate or worse cytology by 45%, but the number with borderline or mild cytology would fall by only 7%, giving an overall reduction of 12% in the number of women with abnormal cytology and 27% in the number with any HR-HPV infection. In the absence of broader cross-protection, the large majority of low-grade and many high-grade abnormalities may still occur in sexually active vaccinated women.

Indexed as

Mass ScreeningAdultAge FactorsAlphapapillomavirusCervix UteriEnglandFemaleHumansMiddle AgedPapillomavirus InfectionsPolymerase Chain ReactionPrevalenceTumor Virus InfectionsUterine Cervical NeoplasmsVaginal Smears

Identifiers

PMID18392052
PMCPMC2391119
OpenAlexW2141405118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.