ArticleNature genetics2008
Genome-wide association analysis identifies 20 loci that influence adult height.
Article in Nature genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 431 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
431 citing papers in PubMed, 8 syntheses or guidelines pooled it, 847 citations in OpenAlex.
- Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.PloS one · 2022Pooled it
- Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort.Journal of medical genetics · 2018Pooled it
- Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis.Journal of thrombosis and haemostasis : JTH · 2017Pooled it
- Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization.Journal of the National Cancer Institute · 2015Pooled it
- Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Pooled it
- Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.Human molecular genetics · 2015Pooled it
- Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.Human molecular genetics · 2013Pooled it
- Genome-wide association study in Han Chinese identifies three novel loci for human height.Human genetics · 2013Pooled it
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- Fast pairwise coalescence enables gene-resolution scans for recent selection in diverse human populations.bioRxiv : the preprint server for biology · 2026Article
- Large scale wheat data integration improves genomic prediction accuracy with the potential to facilitate international breeding collaborations.Communications biology · 2026Article
- An Overview of ADAMTS Proteases.Methods in molecular biology (Clifton, N.J.) · 2026Review
- The Impact of Nutrition, Genetics, Environment, and Common Issues on Adolescent Growth and Development.Advances in experimental medicine and biology · 2026Review
- Polymorphism of the HMGA2 gene in Polish children and adolescents with short stature and diverse growth hormone secretion.Journal of applied genetics · 2025Article
- Characterization of genomic diversity and population structure of worldwide Duroc subpopulations and other pig breeds.Genetics, selection, evolution : GSE · 2025Article
- Genetic Variability in Child Growth Among South American Populations: A Perspective Integrating Population Genetics, Growth Standards, and Precision Growth Medicine.International journal of molecular sciences · 2025Review
- The genetic basis of human height.Nature reviews. Genetics · 2025Review
- Forensic skeletal and molecular anthropology face to face: Combining expertise for identification of human remains.Annals of the New York Academy of Sciences · 2025Review
- Leveraging genome-wide association analyses with chip and imputed data emerges potential pleiotropic region for four duck growth traits.Scientific reports · 2025Article
- Associations between carotid artery intima-media thickness, traditional risk factors and proteins.NPJ cardiovascular health · 2025Article
371 more citing papers are in PubMed but not listed here.
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Authors and funding
42 authors at 13 institutions in 3 countries.
Funding
Abstract
Adult height is a model polygenic trait, but there has been limited success in identifying the genes underlying its normal variation. To identify genetic variants influencing adult human height, we used genome-wide association data from 13,665 individuals and genotyped 39 variants in an additional 16,482 samples. We identified 20 variants associated with adult height (P < 5 x 10(-7), with 10 reaching P < 1 x 10(-10)). Combined, the 20 SNPs explain approximately 3% of height variation, with a approximately 5 cm difference between the 6.2% of people with 17 or fewer 'tall' alleles compared to the 5.5% with 27 or more 'tall' alleles. The loci we identified implicate genes in Hedgehog signaling (IHH, HHIP, PTCH1), extracellular matrix (EFEMP1, ADAMTSL3, ACAN) and cancer (CDK6, HMGA2, DLEU7) pathways, and provide new insights into human growth and developmental processes. Finally, our results provide insights into the genetic architecture of a classic quantitative trait.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.