Evidence map›Paper›PMID 18391836›Full record

ArticlePediatric research2008

Plasma concentrations of carbohydrates and sugar alcohols in term newborns after milk feeding.

Laura D Brown, Claudio Cavalli, Jeri E F Harwood, Annachiara Casadei, Cecilia C Teng, Cristina Traggiai, Giovanni Serra, Giulio Bevilacqua, Frederick C Battaglia

Open access · bronzeAbstract read
In one paragraph

Article in Pediatric research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Secondary Reporting of G6PD Deficiency on Newborn Screening.International journal of neonatal screening · 2023
    Article
  3. Synergistic Effects of Milk-Derived Exosomes and Galactose onInternational journal of molecular sciences · 2021
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Laura D BrownDepartment of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA. laura.brown@uchsc.edu
Claudio Cavalli
Jeri E F Harwood
Annachiara Casadei
Cecilia C Teng
Cristina Traggiai
Giovanni Serra
Giulio Bevilacqua
Frederick C Battaglia
University of Colorado Denver · USUniversity of Parma · ITIstituto Giannina Gaslini · IT

Funding

ZORVIRAX ORAL SUSPENSION FOR SEVERE CHILDHOOD HERPES VIRUS INFECTIONSM01RR000069 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 1985 to 2008
$22.1M
FETAL VELOCIMETRY AND AMINO ACID TRANSPORT IN PREGNANCYR01HD034837 · NICHD · UNIVERSITY OF COLORADO DENVER · PI BATTAGLIA, FREDERICK C · 1997 to 2007
$2.0M
Biosynthetic studies on the heterocycle-containing thiopeptide natural productsF32GM089018 · NIGMS · HARVARD MEDICAL SCHOOL · PI BROWN, LAURA CAROLINE · 2009 to 2010
$98k
NCRR NIH HHS M01 RR000069NCRR NIH HHS M01 RR 00069NICHD NIH HHS 5 R01 HD 34837-06NICHD NIH HHS R01 HD034837NIGMS NIH HHS F32 GM089018
6 · The paper itself

Abstract

Nonglucose carbohydrates such as galactose, mannose, and inositol play a clinically important role in fetal and neonatal nutrition, though little is known about their metabolism in the neonate. The aim of this study was to determine whether postprandial changes in plasma carbohydrate and sugar alcohol concentrations are affected by clinical variables such as postnatal age (PNA), milk type, feeding volume, or feeding duration in term newborns. Neonates (n = 26) taking intermittent enteral feedings were enrolled. Blood samples were obtained at baseline (immediately before the start of a feeding) and at 2-3 subsequent time points up to 110 min. Postprandial rise was only observed for plasma glucose concentrations [Glu] and plasma galactose concentrations [Gal] and clinical variables did not predict this change. Despite equimolar delivery in milk, the median of [Glu] rise minus [Gal] rise from baseline to second postprandial plasma sample was 674 microM (-38, 3333 microM; p < 0.0001), reflecting efficient hepatic first-pass metabolism of galactose. A significant PNA effect on [Gal] was observed such that for each day PNA there was an 18% decrease in [Gal] (p = 0.03). [Gal] are a function of PNA, suggesting maintenance of a significant ductus venosus shunt in term infants.

Indexed as

Postprandial PeriodAnimalsBlood GlucoseBreast FeedingCarbohydratesGalactoseHumansInfant FormulaInfant, NewbornMilkSugar AlcoholsBlood GlucoseCarbohydratesGalactoseSugar Alcohols

Identifiers

PMID18391836
PMCPMC2903005
OpenAlexW1975049058

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.