ReviewPhysiological reviews2008
Cardiac remodeling in obesity.
Review in Physiological reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02677558 (The Impact of Obesity on Cardiac Function in Pregnancy), which is not on this map. Cited by 347 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Obesity on Cardiac Function in Pregnancy
Who cites it
347 citing papers in PubMed, 1 synthesis or guideline pooled it, 716 citations in OpenAlex.
- Effects of products designed to modulate the gut microbiota on hyperlipidaemia.European journal of nutrition · 2019Pooled it
- Precocious Preclinical Cardiovascular Sonographic Markers in Metabolically Healthy and Unhealthy Childhood Obesity.Frontiers in endocrinology · 2020Trial
- No Obesity Paradox in Pediatric Patients With Dilated Cardiomyopathy.JACC. Heart failure · 2018Trial
- Dietary Matcha Attenuates High-Fat High-Sugar Diet-Induced Cardiomyocyte Hypertrophy in Association with Gut Microbiota Remodeling in Mice.Nutrients · 2026Article
- Differential Biventricular Strain Recovery With Selective Fibrosis Biomarker Regression After Sleeve Gastrectomy: A Prospective CMR Feature-Tracking Study.Obesity surgery · 2026Article
- Short-Term Cardiac Effects of Bariatric Surgery: Is Weight Loss Alone Sufficient in Metabolically Healthy Morbidly Obese Patients?Journal of cardiovascular development and disease · 2026Article
- Impact of MetS on Long-Term Prognosis Among STEMI Patients Treated with pPCI-Ten-Year Follow-Up Study.Medical sciences (Basel, Switzerland) · 2026Article
- Intersecting Molecular Pathways in Cardiovascular Disease and Diabetes Mellitus: Emerging Roles of Inflammation and Therapeutics.Diabetes/metabolism research and reviews · 2026Review
- Immediate Effect of Whole-Body Vibration Exercise Performed in Vertical Versus Side-Alternating Displacement Modes on Physiological Parameters, Perception of Effort, Strength and Functionality in Adults with Obesity.Diagnostics (Basel, Switzerland) · 2026Article
- Sex-specific obesity paradox and type 2 myocardial infarction in acute ischemic stroke (AIS) patients.Biology of sex differences · 2026Article
- Left ventricular hypertrophy and myocardial fibrosis in heart failure with preserved ejection fraction: mechanisms and treatment.European heart journal · 2026Review
- Treatment with Capsinoids Promotes Impaired Cardiomyocyte Contractility in Obesity without Positively Modulating Metabolic Parameters.Arquivos brasileiros de cardiologia · 2026Article
- The C-reactive protein-to-body mass index ratio predicts prognosis in patients with different types of heart failure.Open medicine (Warsaw, Poland) · 2026Article
- Combined antiretroviral therapy with low- or normal-protein, high-calorie diets appears to induce significant deleterious electrocardiographic changes in a rodent model.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Endocrine regulation of cardiac fibrosis: implications for HFpEF.Frontiers in endocrinology · 2026Review
- Obesity-Associated Cardiac Fibrosis: Mechanisms and Emerging Therapeutic Targets.Vascular health and risk management · 2026Review
- Effects of body mass index on left ventricular function: An echocardiographic comparison between obese and nonobese individuals.Physiological reports · 2025Article
- Endosomal Mechanisms in Heart Failure Pathophysiology.Current heart failure reports · 2025Review
- Review
- Prognostic Impact of Obesity, Cardiometabolic Risk Factors, and Vascular Function Markers on Outcomes in Ischemic Cardiomyopathy.Journal of clinical medicine · 2025Article
287 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The dramatic increase in the prevalence of obesity and its strong association with cardiovascular disease have resulted in unprecedented interest in understanding the effects of obesity on the cardiovascular system. A consistent, but puzzling clinical observation is that obesity confers an increased susceptibility to the development of cardiac disease, while at the same time affording protection against subsequent mortality (termed the obesity paradox). In this review we focus on evidence available from human and animal model studies and summarize the ways in which obesity can influence structure and function of the heart. We also review current hypotheses regarding mechanisms linking obesity and various aspects of cardiac remodeling. There is currently great interest in the role of adipokines, factors secreted from adipose tissue, and their role in the numerous cardiovascular complications of obesity. Here we focus on the role of leptin and the emerging promise of adiponectin as a cardioprotective agent. The challenge of understanding the association between obesity and heart failure is complicated by the multifaceted interplay between various hemodynamic, metabolic, and other physiological factors that ultimately impact the myocardium. Furthermore, the end result of obesity-associated changes in the myocardial structure and function may vary at distinct stages in the progression of remodeling, may depend on the individual pathophysiology of heart failure, and may even remain undetected for decades before clinical manifestation. Here we summarize our current knowledge of this complex yet intriguing topic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.