ArticleThe Journal of cell biology2008
straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Deficiency in transmitter release triggers homeostatic transcriptional changes that increase presynaptic excitability.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- CaeLife · 2024Article
- Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration.PLoS genetics · 2024Article
- CabioRxiv : the preprint server for biology · 2024Article
- Drosophila pain sensitization and modulation unveiled by a novel pain model and analgesic drugs.PloS one · 2023Article
- Role of α2δ-3 in regulating calcium channel localization at presynaptic active zones during homeostatic plasticity.Frontiers in molecular neuroscience · 2023Article
- Regulation of presynaptic CaeLife · 2022Article
- Mechanisms controlling the trafficking, localization, and abundance of presynaptic CaFrontiers in molecular neuroscience · 2022Review
- Different functions of two putative Drosophila αScientific reports · 2020Article
- The calcium channel subunit αNature communications · 2019Article
- PeripheralPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Glutamate signaling at cytoneme synapses.Science (New York, N.Y.) · 2019Article
- Deletion of the CaFrontiers in cellular neuroscience · 2019Article
- The CaScientific reports · 2018Article
- Unraveling Novel Mechanisms of Neurodegeneration Through a Large-Scale Forward Genetic Screen inFrontiers in genetics · 2018Review
- Voltage-gated calcium channel αF1000Research · 2018Review
- Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse.PLoS genetics · 2017Article
- α2δ-3 Is Required for Rapid Transsynaptic Homeostatic Signaling.Cell reports · 2016Article
- Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca(2+) Channels.Scientific reports · 2016Article
- The Landscape of A-to-I RNA Editome Is Shaped by Both Positive and Purifying Selection.PLoS genetics · 2016Article
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Authors and funding
5 authors.
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Abstract
In a screen to identify genes involved in synaptic function, we isolated mutations in Drosophila melanogaster straightjacket (stj), an alpha(2)delta subunit of the voltage-gated calcium channel. stj mutant photoreceptors develop normal synaptic connections but display reduced "on-off" transients in electroretinogram recordings, indicating a failure to evoke postsynaptic responses and, thus, a defect in neurotransmission. stj is expressed in neurons but excluded from glia. Mutants exhibit endogenous seizure-like activity, indicating altered neuronal excitability. However, at the synaptic level, stj larval neuromuscular junctions exhibit approximately fourfold reduction in synaptic release compared with controls stemming from a reduced release probability at these synapses. These defects likely stem from destabilization of Cacophony (Cac), the primary presynaptic alpha(1) subunit in D. melanogaster. Interestingly, neuronal overexpression of cac partially rescues the viability and physiological defects in stj mutants, indicating a role for the alpha(2)delta Ca(2+) channel subunit in mediating the proper localization of an alpha(1) subunit at synapses.
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