Evidence map›Paper›PMID 18391032›Full record

ArticleAntimicrobial agents and chemotherapy2008

First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States.

Rodrigo E Mendes, Lalitagauri M Deshpande, Mariana Castanheira, Joseph DiPersio, Michael A Saubolle, Ronald N Jones

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Methicillin-resistantFrontiers in microbiology · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Molecular Mechanisms of Drug Resistance inInternational journal of molecular sciences · 2022
    Review
  13. Communications medicine · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Emergence of linezolid-resistant Staphylococcus epidermidis in the tertiary children's hospital in Cracow, Poland.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  18. Antimicrobial Resistance in ESKAPE Pathogens.Clinical microbiology reviews · 2020
    Review
  19. Molecular characteristics and predictors of mortality among Gram-positive bacteria isolated from bloodstream infections in critically ill patients during a 5-year period (2012-2016).European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  20. Antibiotic Resistance and the MRSA Problem.Microbiology spectrum · 2019
    Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rodrigo E MendesJMI Laboratories, North Liberty, IA 52317, USA.
Lalitagauri M Deshpande
Mariana Castanheira
Joseph DiPersio
Michael A Saubolle
Ronald N Jones

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Linezolid resistance has dominantly been mediated by mutations in 23S rRNA or ribosomal protein L4 genes. Recently, cfr has demonstrated the ability to produce a phenotype of resistance to not only oxazolidinones, but also other antimicrobial classes (phenicols, lincosamides, pleuromutilins, and streptogramin A). We describe the first detection of cfr-mediated linezolid resistance in Staphylococcus aureus and Staphylococcus epidermidis recovered from human infection cases monitored during the 2007 LEADER Program.

Indexed as

AcetamidesAnti-Bacterial AgentsAnti-Infective AgentsBacterial ProteinsDrug Resistance, BacterialHumansLinezolidMethyltransferasesMicrobial Sensitivity TestsMolecular Sequence DataOxazolidinonesSequence Analysis, DNAStaphylococcal InfectionsStaphylococcus aureusStaphylococcus epidermidisAcetamidesAnti-Bacterial AgentsAnti-Infective AgentsBacterial ProteinsLinezolidMethyltransferasesOxazolidinones

Identifiers

PMID18391032
PMCPMC2415768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.