ArticleMolecular biology and evolution2008
Selection on amino acid substitutions in Arabidopsis.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Patterns of Genomic Diversity in a Fig-Associated Close Relative of Caenorhabditis elegans.Genome biology and evolution · 2024Article
- Globally Relaxed Selection and Local Adaptation in Boechera stricta.Genome biology and evolution · 2022Article
- Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared with mice andGenome research · 2021Article
- Population Genomics of Transitions to Selfing in Brassicaceae Model Systems.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Impact of demography on linked selection in two outcrossing Brassicaceae species.Ecology and evolution · 2019Article
- Higher Rates of Protein Evolution in the Self-Fertilizing Plant Arabidopsis thaliana than in the Out-Crossers Arabidopsis lyrata and Arabidopsis halleri.Genome biology and evolution · 2018Article
- Selfing in Haploid Plants and Efficacy of Selection: Codon Usage Bias in the Model Moss Physcomitrella patens.Genome biology and evolution · 2017Article
- Patterns of Substitution Rate Variation at Many Nuclear Loci in Two Species Trios in the Brassicaceae Partitioned with ANOVA.Journal of molecular evolution · 2016Article
- Lineage-specific sequence evolution and exon edge conservation partially explain the relationship between evolutionary rate and expression level in A. thaliana.Molecular ecology · 2015Article
- The impact of linked selection on plant genomic variation.Briefings in functional genomics · 2014Article
- Evolutionary consequences of self-fertilization in plants.Proceedings. Biological sciences · 2013Review
- ZRT1 Harbors an Excess of Nonsynonymous Polymorphism and Shows Evidence of Balancing Selection in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2013Article
- A comparison of models to infer the distribution of fitness effects of new mutations.Genetics · 2013Article
- Adaptive evolution and effective population size in wild house mice.Molecular biology and evolution · 2012Article
- Weak selection and protein evolution.Genetics · 2012Review
- Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus Capsella.BMC evolutionary biology · 2012Article
- Evidence for widespread positive and purifying selection across the European rabbit (Oryctolagus cuniculus) genome.Molecular biology and evolution · 2012Article
- Slow but not low: genomic comparisons reveal slower evolutionary rate and higher dN/dS in conifers compared to angiosperms.BMC evolutionary biology · 2012Article
- Rates of evolution in stress-related genes are associated with habitat preference in two Cardamine lineages.BMC evolutionary biology · 2012Article
- Methods to detect selection on noncoding DNA.Methods in molecular biology (Clifton, N.J.) · 2012Review
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Studies of nucleotide diversity have found an excess of low-frequency amino acid polymorphisms segregating in Arabidopsis thaliana, suggesting a predominance of weak purifying selection acting on amino acid polymorphism in this inbreeding species. Here, we investigate levels of diversity and divergence at synonymous and nonsynonymous sites in 6 circumpolar populations of the outbreeding Arabidopsis lyrata and compare these results with A. thaliana, to test for differences in mutation and selection parameters across genes, populations, and species. We find that A. lyrata shows an excess of low-frequency nonsynonymous polymorphisms both within populations and species wide, consistent with weak purifying selection similar to the patterns observed in A. thaliana. Furthermore, nonsynonymous polymorphisms tend to be more restricted in their population distribution in A. lyrata, consistent with purifying selection preventing their geographic spread. Highly expressed genes show a reduced ratio of amino acid to synonymous change for both polymorphism and fixed differences, suggesting a general pattern of stronger purifying selection on high-expression proteins.
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