ReviewGlycobiology2008
Structural glycobiology: a game of snakes and ladders.
Review in Glycobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed.
- Analysis of Glycan Recognition by Concanavalin A Using Absolute Binding Free Energy Calculations.Journal of chemical information and modeling · 2024Article
- Editors' Choice-Perspective-Deciphering the Glycan Kryptos by Solid-State Nanopore Single-Molecule Sensing: A Call for Integrated Advancements Across Glyco- and Nanopore Science.ECS sensors plus · 2024Article
- The three-sided right-handed β-helix is a versatile fold for glycan interactions.Glycobiology · 2024Review
- Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021-2022.Pathogens (Basel, Switzerland) · 2022Article
- Modeling pyranose ring pucker in carbohydrates using machine learning and semi-empirical quantum chemical methods.Journal of computational chemistry · 2022Article
- Development and Evaluation of GlycanDock: A Protein-Glycoligand Docking Refinement Algorithm in Rosetta.The journal of physical chemistry. B · 2021Article
- Carbohydrate-Protein Interactions: Advances and Challenges.Communications in information and systems · 2021Article
- A Role for Monosaccharides in Nucleation Inhibition and Transport of Collagen.Bioelectricity · 2020Article
- Drude Polarizable Force Field Parametrization of Carboxylate andJournal of chemical theory and computation · 2019Article
- Surveying silicon nitride nanopores for glycomics and heparin quality assurance.Nature communications · 2018Article
- Applying Pose Clustering and MD Simulations To Eliminate False Positives in Molecular Docking.Journal of chemical information and modeling · 2018Article
- The Use of NMR to Study Transient Carbohydrate-Protein Interactions.Frontiers in molecular biosciences · 2018Review
- A High-Throughput Mass-Spectrometry-Based Assay for Identifying the Biochemical Functions of Putative Glycosidases.Chembiochem : a European journal of chemical biology · 2017Article
- The β-reducing end in α(2-8)-polysialic acid constitutes a unique structural motif.Glycobiology · 2017Article
- Effects of varying the 6-position oxidation state of hexopyranoses: a systematic comparative computational analysis of 48 monosaccharide stereoisomers.Journal of molecular modeling · 2017Article
- Residue-centric modeling and design of saccharide and glycoconjugate structures.Journal of computational chemistry · 2017Article
- O-Acetyl Side-Chains in Monosaccharides: Redundant NMR Spin-Couplings and Statistical Models for Acetate Ester Conformational Analysis.The journal of physical chemistry. B · 2017Article
- HPLC-Assisted Automated Oligosaccharide Synthesis: Implementation of the Autosampler as a Mode of the Reagent Delivery.The Journal of organic chemistry · 2016Article
- Design and Synthesis of Nanofibers of Self-assembledTetrahedron · 2016Article
- Combining 3D structure with glycan array data provides insight into the origin of glycan specificity.Glycobiology · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Oligo- and polysaccharides are infamous for being extremely flexible molecules, populating a series of well-defined rotational isomeric states under physiological conditions. Characterization of this heterogeneous conformational ensemble has been a major obstacle impeding high-resolution structure determination of carbohydrates and acting as a bottleneck in the effort to understand the relationship between the carbohydrate structure and function. This challenge has compelled the field to develop and apply theoretical and experimental methods that can explore conformational ensembles by both capturing and deconvoluting the structural and dynamic properties of carbohydrates. This review focuses on computational approaches that have been successfully used in combination with experiment to detail the three-dimensional structure of carbohydrates in a solution and in a complex with proteins. In addition, emerging experimental techniques for three-dimensional structural characterization of carbohydrate-protein complexes and future challenges in the field of structural glycobiology are discussed. The review is divided into five sections: (1) The complexity and plasticity of carbohydrates, (2) Predicting carbohydrate-protein interactions, (3) Calculating relative and absolute binding free energies for carbohydrate-protein complexes, (4) Emerging and evolving techniques for experimental characterization of carbohydrate-protein structures, and (5) Current challenges in structural glycoscience.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.