ArticleApplied and environmental microbiology2008
Characterization of the RND-type multidrug efflux pump MexAB-OprM of the plant pathogen Pseudomonas syringae.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 75 citations in OpenAlex.
- Transcriptome-guided discovery of novel plant-associated genes in a rhizosphere Pseudomonas.Microbiome · 2025Article
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- Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa.The Journal of antibiotics · 2024Article
- An efflux pump deletion mutant enabling the discovery of a macrolide as an overlooked anti-P. aeruginosa active compound.The Journal of antibiotics · 2023Article
- Impact of benzalkonium chloride, benzethonium chloride and chloroxylenol on bacterial antimicrobial resistance.Journal of applied microbiology · 2022Review
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- Identification of Indole-3-Acetic Acid-Regulated Genes inJournal of bacteriology · 2022Article
- Responses of the bacterial community of tobacco phyllosphere to summer climate and wildfire disease.Frontiers in plant science · 2022Article
- Resistance-Nodulation-Division Efflux Pump, LexABC, Contributes to Self-Resistance of the Phenazine Di-Frontiers in microbiology · 2021Article
- Role of Two Sets of RND-Type Multidrug Efflux Pump Transporter Genes,The plant pathology journal · 2020Article
- Genome-Wide Transposon Screen of amBio · 2019Article
- Antibiotic ResistantFoods (Basel, Switzerland) · 2019Review
- Benzalkonium Chlorides: Uses, Regulatory Status, and Microbial Resistance.Applied and environmental microbiology · 2019Review
- Transposon mutagenesis revealsPeerJ · 2019Article
- Flow Cytometric Analysis of Efflux by Dye Accumulation.Frontiers in microbiology · 2019Article
- Article
- The population genetic test Tajima's D identifies genes encoding pathogen-associated molecular patterns and other virulence-related genes in Ralstonia solanacearum.Molecular plant pathology · 2018Article
- Genomic and Transcriptomic Insights into How Bacteria Withstand High Concentrations of Benzalkonium Chloride Biocides.Applied and environmental microbiology · 2018Article
- Profiling the extended phenotype of plant pathogens: Challenges in Bacterial Molecular Plant Pathology.Molecular plant pathology · 2017Review
- Comparative genomics of 43 strains of Xanthomonas citri pv. citri reveals the evolutionary events giving rise to pathotypes with different host ranges.BMC genomics · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In gram-negative bacteria, transporters belonging to the RND family are the transporters most relevant for resistance to antimicrobial compounds. In Pseudomonas aeruginosa, a clinically important pathogen, the RND-type pump MexAB-OprM has been recognized as one of the major multidrug efflux systems. Here, homologues of MexAB-OprM in the plant pathogens Pseudomonas syringae pv. phaseolicola 1448A, P. syringae pv. syringae B728a, and P. syringae pv. tomato DC3000 were identified, and mexAB-oprM-deficient mutants were generated. Determination of MICs revealed that mutation of MexAB-OprM dramatically reduced the tolerance to a broad range of antimicrobials. Moreover, the ability of the mexAB-oprM-deficient mutants to multiply in planta was reduced. RNA dot blot hybridization revealed growth-dependent regulation of the mexAB-oprM operon in P. syringae; the expression of this operon was maximal in early exponential phase and decreased gradually during further growth.
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