ArticleBiophysical journal2008
A magneto-optic route toward the in vivo diagnosis of malaria: preliminary results and preclinical trial data.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 93 citations in OpenAlex.
- Magneto-optical microscopy platform for quantitative imaging of hemozoin in blood for malaria diagnosis.Biomedical optics express · 2026Article
- Hemozoin as a Diagnostic Biomarker: A Scoping Review of Next-Generation Malaria Detection Technologies.Biosensors · 2026Review
- Magneto-optical assessment of Plasmodium parasite growth via hemozoin crystal size.Scientific reports · 2024Article
- Reducing data dimension boosts neural network-based stage-specific malaria detection.Scientific reports · 2022Article
- Evaluation of a haemozoin-based rapid diagnostic test for diagnosis of imported malaria during the phase of prevention of reestablishment in Sri Lanka.Malaria journal · 2022Article
- Review of Microdevices for Hemozoin-Based Malaria Detection.Biosensors · 2022Review
- Multi-Omics Advancements towardsDiagnostics (Basel, Switzerland) · 2021Review
- Sensitive detection of Plasmodium vivax malaria by the rotating-crystal magneto-optical method in Thailand.Scientific reports · 2021Article
- An ON-OFF Magneto-Optical Probe of Anisotropic Biofluid Crystals: AIEEE transactions on magnetics · 2021Article
- Magneto-optical diagnosis of symptomatic malaria in Papua New Guinea.Nature communications · 2021Article
- Field validation of a magneto-optical detection device (Gazelle) for portable point-of-care Plasmodium vivax diagnosis.PloS one · 2021Article
- Quantitative diffuse optical spectroscopy for noninvasive measurements of the malaria pigment hemozoin.Biomedical optics express · 2020Article
- Detection of malaria parasites in dried human blood spots using mid-infrared spectroscopy and logistic regression analysis.Malaria journal · 2019Article
- Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis.Nature communications · 2019Article
- Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.Chemical reviews · 2019Review
- Malaria and the 'last' parasite: how can technology help?Malaria journal · 2018Review
- Growth of Plasmodium falciparum in response to a rotating magnetic field.Malaria journal · 2018Article
- Towards a needle-free diagnosis of malaria: in vivo identification and classification of red and white blood cells containing haemozoin.Malaria journal · 2017Article
- NMR relaxation properties of the synthetic malaria pigment β-hematin.Scientific reports · 2017Article
- Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans.International journal of nanomedicine · 2017Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the development of magneto-optic technology for the rapid quantitative diagnosis of malaria that may also be realizable in a noninvasive format. Hemozoin, the waste product of malarial parasitic action on hemoglobin, is produced in a form that under the action of an applied magnetic field gives rise to an induced optical dichroism characteristic of the hemozoin concentration. Here we show that precise measurement of this induced dichroism may be used to determine the level of malarial infection because this correlates, albeit in a complex manner throughout the infection cycle, with the concentration of hemozoin in the blood and tissues of infected patients. Under conservative assumptions for the production of hemozoin as a function of parasitemia, initial results indicate that the technique can match or exceed other current diagnostic techniques. The validity of the approach is confirmed by a small preliminary clinical trial on 13 patients, and measurements on live parasitized cells obtained from in vitro culture verify the possibility of producing in vivo diagnostic instrumentation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.