ArticleBiophysical journal2008
Synthetic nanopores as a test case for ion channel theories: the anomalous mole fraction effect without single filing.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The Complex Proteolipidic Behavior of the SARS-CoV-2 Envelope Protein Channel: Weak Selectivity and Heterogeneous Oligomerization.International journal of molecular sciences · 2023Article
- Physics of the Nuclear Pore Complex: Theory, Modeling and Experiment.Physics reports · 2021Article
- Modeling the Device Behavior of Biological and Synthetic Nanopores with Reduced Models.Entropy (Basel, Switzerland) · 2020Article
- The mixture effect on ionic selectivity and permeability of nanotubes.Nanoscale advances · 2020Article
- Ion selectivity of graphene nanopores.Nature communications · 2016Article
- Fabrication of Nanochannels.Materials (Basel, Switzerland) · 2015Review
- Interacting ions in biophysics: real is not ideal.Biophysical journal · 2013Review
- Ion correlations in nanofluidic channels: effects of ion size, valence, and concentration on voltage- and pressure-driven currents.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Slowing down DNA translocation through a nanopore in lithium chloride.Nano letters · 2012Article
- Anion currents in yeast K+ transporters (TRK) characterize a structural homologue of ligand-gated ion channels.Pflugers Archiv : European journal of physiology · 2011Article
- Selectivity sequences in a model calcium channel: role of electrostatic field strength.European biophysics journal : EBJ · 2011Article
- Testing the applicability of Nernst-Planck theory in ion channels: comparisons with Brownian dynamics simulations.PloS one · 2011Article
- DNA strands attached inside single conical nanopores: ionic pore characteristics and insight into DNA biophysics.The Journal of membrane biology · 2011Article
- Simulations of calcium channel block by trivalent cations: Gd(3+) competes with permeant ions for the selectivity filter.Biochimica et biophysica acta · 2010Article
- Sieving experiments and pore diameter: it's not a simple relationship.European biophysics journal : EBJ · 2010Article
- Energy variational analysis of ions in water and channels: Field theory for primitive models of complex ionic fluids.The Journal of chemical physics · 2010Article
- Enhancement of transport selectivity through nano-channels by non-specific competition.PLoS computational biology · 2010Article
- Reinterpreting the anomalous mole fraction effect: the ryanodine receptor case study.Biophysical journal · 2009Article
- Ionic selectivity in L-type calcium channels by electrostatics and hard-core repulsion.The Journal of general physiology · 2009Article
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5 authors.
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Abstract
The predictions of a theory for the anomalous mole fraction effect (AMFE) are tested experimentally with synthetic nanopores in plastic. The negatively charged synthetic nanopores under consideration are highly cation selective and 50 A in diameter at their smallest point. These pores exhibit an AMFE in mixtures of Ca(2+) and monovalent cations. An AMFE occurs when the conductance through a pore is lower in a mixture of salts than in the pure salts at the same concentration. For ion channels, the textbook interpretation of the AMFE is that multiple ions move through the pore in coordinated, single-file motion. However, because the synthetic nanopores are so wide, their AMFE shows that single filing is not necessary for the AMFE. It is shown that the AMFE in the synthetic nanopores is explained by a theory of preferential ion selectivity. The unique properties of the synthetic nanopores allow us to experimentally confirm several predictions of this theory. These same properties make synthetic nanopores an interesting new platform to test theories of ion channel permeation and selectivity in general.
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