ArticleThe Plant cell2008
Phosducin-Like Protein 3 is required for microtubule-dependent steps of cell division but not for meristem growth in Arabidopsis.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- The evolutionarily conserved PhLP3 is essential for sperm development in Drosophila melanogaster.PloS one · 2024Article
- HOP co-chaperones contribute to GA signaling by promoting the accumulation of the F-box protein SNE in Arabidopsis.Plant communications · 2023Article
- Comparative transcriptomics analysis at the key stage of maize ear development dissect heterosis.The plant genome · 2023Article
- Phosducin-like proteinFrontiers in microbiology · 2023Article
- The co-chaperone HOP participates in TIR1 stabilisation and in auxin response in plants.Plant, cell & environment · 2022Article
- The co-chaperone HOP3 participates in jasmonic acid signaling by regulating CORONATINE-INSENSITIVE 1 activity.Plant physiology · 2021Article
- A Thioredoxin Domain-Containing Protein Interacts withInternational journal of molecular sciences · 2018Article
- Identification of a locus conferring dominant resistance to maize rough dwarf disease in maize.Scientific reports · 2018Article
- Characterization of a protozoan Phosducin-like protein-3 (PhLP-3) reveals conserved redox activity.PloS one · 2018Article
- Txndc9 Is Required for Meiotic Maturation of Mouse Oocytes.BioMed research international · 2017Article
- Genome management and mismanagement--cell-level opportunities and challenges of whole-genome duplication.Genes & development · 2015Review
- Microtubules in plants.The arabidopsis book · 2015Article
- A microbial avenue to cell cycle control in the plant superkingdom.The Plant cell · 2014Article
- MAPs: cellular navigators for microtubule array orientations in Arabidopsis.Plant cell reports · 2014Review
- Modulation of phosducin-like protein 3 (PhLP3) levels promotes cytoskeletal remodelling in a MAPK and RhoA-dependent manner.PloS one · 2011Article
- Prefoldin 6 is required for normal microtubule dynamics and organization in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Given the central role of cell division in meristems, one might expect meristem growth to be regulated by mitotic checkpoints, including checkpoints for correct microtubule function. Here, we studied the role of two close Phosducin-Like Protein 3 homologs from Arabidopsis thaliana (PLP3a and PLP3b) in the microtubule assembly pathway and determined the consequences of inhibiting PLP3a and PLP3b expression in the meristem. PLP3 function is essential in Arabidopsis: impairing PLP3a and PLP3b expression disrupted microtubule arrays and caused polyploidy, aneuploidy, defective cytokinesis, and disoriented cell growth. Consistent with a role in microtubule formation, PLP3a interacted with beta-tubulin in the yeast two-hybrid assay and, when overexpressed, increased resistance to drugs that inhibit tubulin polymerization. Inhibition of PLP3 function targeted to the meristem caused severe mitotic defects, but the cells carried on cycling through DNA replication and abortive cytokinesis. Thus, we showed that PLP3 is involved in microtubule formation in Arabidopsis and provided genetic evidence that cell viability and growth in the meristem are not subordinate to successful completion of microtubule-dependent steps of cell division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.