ArticleThe Journal of biological chemistry2008
Signaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulation.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 81 citations in OpenAlex.
- A stress-responsive p38 signaling axis in choanoflagellates.RSC chemical biology · 2025Article
- Domain Analysis and Motif Matcher (DAMM): A Program to Predict Selectivity Determinants inMolecules (Basel, Switzerland) · 2021Article
- Structural characterization and computational analysis of PDZ domains in Monosiga brevicollis.Protein science : a publication of the Protein Society · 2020Article
- Temperature sensitivities of metazoan and pre-metazoan Src kinases.Biochemistry and biophysics reports · 2020Article
- Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions.International journal of molecular sciences · 2020Review
- Genomic Survey of Tyrosine Kinases Repertoire inEvolutionary bioinformatics online · 2020Article
- MotifAnalyzer-PDZ: A computational program to investigate the evolution of PDZ-binding target specificity.Protein science : a publication of the Protein Society · 2019Article
- The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases.Critical reviews in biochemistry and molecular biology · 2018Review
- Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates.Protein science : a publication of the Protein Society · 2018Article
- Src signaling in a low-complexity unicellular kinome.Scientific reports · 2018Article
- Genome-Wide Identification and Characterization of Tyrosine Kinases in the Silkworm, Bombyx mori.International journal of molecular sciences · 2018Article
- Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase.The Journal of biological chemistry · 2017Article
- Phosphotyrosine signalling and the origin of animal multicellularity.Proceedings. Biological sciences · 2017Article
- Auto-thiophosphorylation activity of Src tyrosine kinase.BMC biochemistry · 2016Article
- Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.PLoS genetics · 2016Article
- Article
- Bacterial influences on animal origins.Cold Spring Harbor perspectives in biology · 2014Review
- Endocytosis and the Src family of non-receptor tyrosine kinases.Biomolecular concepts · 2014Review
- Regulation of Src and Csk nonreceptor tyrosine kinases in the filasterean Ministeria vibrans.Biochemistry · 2014Article
- SRC-family tyrosine kinases in oogenesis, oocyte maturation and fertilization: an evolutionary perspective.Advances in experimental medicine and biology · 2014Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Choanoflagellates, unicellular organisms that are closely related to metazoans, possess cell adhesion and signaling proteins previously thought to be unique to animals, suggesting that these components may have played roles in the evolution of metazoan multicellularity. We have cloned, expressed, and purified the nonreceptor tyrosine kinase MbSrc1 from the choanoflagellate Monosiga brevicollis. The kinase has the same domain arrangement as mammalian Src kinases, and we find that the individual Src homology 3 (SH3), SH2, and catalytic domains have similar functions to their mammalian counterparts. In contrast to mammalian c-Src, the SH2 and catalytic domains of MbSrc1 do not appear to be functionally coupled. We cloned and expressed the M. brevicollis homolog of c-Src C-terminal kinase (MbCsk) and showed that it phosphorylates the C terminus of MbSrc1, yet this phosphorylation does not inhibit MbSrc to the same degree seen in the mammalian Src/Csk pair. Thus, Src autoinhibition likely evolved more recently within the metazoan lineage, and it may have played a role in the establishment of intercellular signaling in metazoans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.