ArticleThe Journal of biological chemistry2008
Partial rescue of the amelogenin null dental enamel phenotype.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 30 citations in OpenAlex.
- A splicing-derived microRNA from amelogenin exon4 regulates enamel formation via control of exon4 splicing and amelogenin expression.Scientific reports · 2026Article
- Mutations Causing X-Linked Amelogenesis Imperfecta Alter miRNA Formation from Amelogenin Exon4.Journal of dental research · 2023Article
- Article
- Dose-Dependent Rescue of KO Amelogenin Enamel by TransgenesFrontiers in physiology · 2017Article
- Weaker dental enamel explains dental decay.PloS one · 2015Article
- Analysis of enamel development using murine model systems: approaches and limitations.Frontiers in physiology · 2014Review
- M180 amelogenin processed by MMP20 is sufficient for decussating murine enamel.Journal of dental research · 2013Article
- Ameloblasts require active RhoA to generate normal dental enamel.European journal of oral sciences · 2013Article
- Mouse genetic background influences the dental phenotype.Cells, tissues, organs · 2013Article
- Dentin sialophosphoprotein and dentin matrix protein-1: Two highly phosphorylated proteins in mineralized tissues.Archives of oral biology · 2012Review
- Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy.PloS one · 2012Article
- Rescue of the murine amelogenin null phenotype with two amelogenin transgenes.European journal of oral sciences · 2011Article
- The use of mouse models to investigate shear bond strength in amelogenesis imperfecta.Journal of dental research · 2011Article
- Leucine-rich amelogenin peptides regulate mineralization in vitro.Journal of dental research · 2011Article
- Amelogenins: Multi-Functional Enamel Matrix Proteins and Their Binding Partners.Journal of oral biosciences · 2011Article
- An amelogenin mutation leads to disruption of the odontogenic apparatus and aberrant expression of Notch1.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2011Article
- The Amelogenin Proteins and Enamel Development in Humans and Mice.Journal of oral biosciences · 2011Article
- Transgenic rescue of enamel phenotype in Ambn null mice.Journal of dental research · 2010Article
- A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked amelogenesis imperfecta.Human molecular genetics · 2010Article
- The leucine rich amelogenin protein (LRAP) adsorbs as monomers or dimers onto surfaces.Journal of structural biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
The amelogenins are the most abundant secreted proteins in developing dental enamel. Enamel from amelogenin (Amelx) null mice is hypoplastic and disorganized, similar to that observed in X-linked forms of the human enamel defect amelogenesis imperfecta resulting from amelogenin gene mutations. Both transgenic strains that express the most abundant amelogenin (TgM180) have relatively normal enamel, but strains of mice that express a mutated amelogenin (TgP70T), which leads to amelogenesis imperfecta in humans, have heterogeneous enamel structures. When Amelx null (KO) mice were mated with transgenic mice that produce M180 (TgM180), the resultant TgM180KO offspring showed evidence of rescue in enamel thickness, mineral density, and volume in molar teeth. Rescue was not observed in the molars from the TgP70TKO mice. It was concluded that a single amelogenin protein was able to significantly rescue the KO phenotype and that one amino acid change abrogated this function during development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.