ArticleIntensive care medicine2008
Computer-assisted glucose control in critically ill patients.
Article in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01085071 (GRIP-COMPASS Trial), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
GRIP-COMPASS Trial: Computer-driven Glucose and Potassium Regulation Program in Intensive Care Patients With COMparison of PotASSium Targets Within normokAlemic Range
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tight glycemic control and computerized decision-support systems: a systematic review.Intensive care medicine · 2009Pooled it
- Effect of high-dose dexamethasone on perioperative lactate levels and glucose control: a randomized controlled trial.Critical care (London, England) · 2015Trial
- The association of early combined lactate and glucose levels with subsequent renal and liver dysfunction and hospital mortality in critically ill patients.Critical care (London, England) · 2017Article
- Space GlucoseControl system for blood glucose control in intensive care patients--a European multicentre observational study.BMC anesthesiology · 2016Observational
- [Glucose control in the critically ill. Innovations and contemporary strategies].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2013Article
- Computerization of the Yale insulin infusion protocol and potential insights into causes of hypoglycemia with intravenous insulin.Diabetes technology & therapeutics · 2013Article
- The future is now: software-guided intensive insulin therapy in the critically ill.Journal of diabetes science and technology · 2013Review
- Glycemic variability and glycemic control in the acutely ill cardiac patient.Heart failure clinics · 2012Review
- "One more thing to think about…" Cognitive burden experienced by intensive care unit nurses when implementing a tight glucose control protocol.Journal of diabetes science and technology · 2012Review
- Barriers and facilitators to the use of computer-based intensive insulin therapy.International journal of medical informatics · 2011Article
- Characteristics and effects of nurse dosing over-rides on computer-based intensive insulin therapy protocol performance.Journal of the American Medical Informatics Association : JAMIA · 2011Article
- The role of insulin therapy and glucose normalisation in patients with acute coronary syndrome.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2011Article
- Continuous subcutaneous glucose monitoring: good enough to use in glucose regulation protocols?Critical care (London, England) · 2011Article
- Trial design: Computer guided normal-low versus normal-high potassium control in critically ill patients: Rationale of the GRIP-COMPASS study.BMC anesthesiology · 2010Article
- Effects of blood glucose transcription mismatches on a computer-based intensive insulin therapy protocol.Intensive care medicine · 2010Article
- Subcutaneous glucose measurements and glucose regulation (?).Intensive care medicine · 2010Article
- Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management.Nature reviews. Neurology · 2010Review
- Hypoglycemia aggravates critical illness-induced neurocognitive dysfunction.Diabetes care · 2010Article
- Organ dysfunction is associated with hyperglycemia in critically ill children.Intensive care medicine · 2010Article
- Implementation and evaluation of a nurse-centered computerized potassium regulation protocol in the intensive care unit--a before and after analysis.BMC medical informatics and decision making · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIntensive insulin therapy is associated with the risk of hypoglycemia and increased costs of material and personnel. We therefore evaluated the safety and efficiency of a computer-assisted glucose control protocol in a large population of critically ill patients. DESIGN AND
settingObservational cohort study in three intensive care units (32 beds) in a 1,300-bed university teaching hospital. PATIENTS: All 2,800 patients admitted to the surgical, neurosurgical, and cardiothoracic units; the study period started at each ICU after implementation of Glucose Regulation for Intensive Care Patients (GRIP), a freely available computer-assisted glucose control protocol. MEASUREMENTS AND
resultsWe analysed compliance in relation to recommended insulin pump rates and glucose measurement frequency. Patients were on GRIP-ordered pump rates 97% of time. Median measurement time was 5min late (IQR 20min early to 34 min late). Hypoglycemia was uncommon (7% of patients for mild hypoglycemia, < 3.5mmol/l; 0.86% for severe hypoglycemia, < 2.2 mmol/l). Our predefined target range (4.0-7.5 mmol/l) was reached after a median of 5.6 h (IQR 0.2-11.8) and maintained for 89% (70-100%) of the remaining stay at the ICU. The number of measurements needed was 5.9 (4.8-7.3) per patient per day. In-hospital mortality was 10.1%.
conclusionsOur computer-assisted glucose control protocol provides safe and efficient glucose regulation in routine intensive care practice. A low rate of hypoglycemic episodes was achieved with a considerably lower number of glucose measurements than used in most other schemes.
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