ArticlePLoS pathogens2008
A novel secretion pathway of Salmonella enterica acts as an antivirulence modulator during salmonellosis.
Article in PLoS pathogens, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
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- Bioinformatic and Molecular Analysis of Inverse Autotransporters from Escherichia coli.mSphere · 2019Article
- Two-Partner Secretion: Combining Efficiency and Simplicity in the Secretion of Large Proteins for Bacteria-Host and Bacteria-Bacteria Interactions.Frontiers in cellular and infection microbiology · 2017Review
- Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family.Genome biology and evolution · 2016Article
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- The Human Antimicrobial Protein Calgranulin C Participates in Control of Helicobacter pylori Growth and Regulation of Virulence.Infection and immunity · 2015Article
- Identification and functional characterization of the novel Edwardsiella tarda effector EseJ.Infection and immunity · 2015Article
- Salmonella acquires ferrous iron from haemophagocytic macrophages.Molecular microbiology · 2014Article
- Helicobacter and salmonella persistent infection strategies.Cold Spring Harbor perspectives in medicine · 2013Review
- Tetracycline accelerates the temporally-regulated invasion response in specific isolates of multidrug-resistant Salmonella enterica serovar Typhimurium.BMC microbiology · 2013Article
- Comprehensive assignment of roles for Salmonella typhimurium genes in intestinal colonization of food-producing animals.PLoS genetics · 2013Article
- Genome expression analysis of nonproliferating intracellular Salmonella enterica serovar Typhimurium unravels an acid pH-dependent PhoP-PhoQ response essential for dormancy.Infection and immunity · 2013Article
- The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton.Cell host & microbe · 2012Article
- The zinc regulated antivirulence pathway of Salmonella is a multiprotein immunoglobulin adhesion system.The Journal of biological chemistry · 2012Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Salmonella spp. are Gram-negative enteropathogenic bacteria that infect a variety of vertebrate hosts. Like any other living organism, protein secretion is a fundamental process essential for various aspects of Salmonella biology. Herein we report the identification and characterization of a horizontally acquired, autonomous and previously unreported secretion pathway. In Salmonella enterica serovar Typhimurium, this novel secretion pathway is encoded by STM1669 and STM1668, designated zirT and zirS, respectively. We show that ZirT is localized to the bacterial outer membrane, expected to adopt a compact beta-barrel conformation, and functions as a translocator for ZirS. ZirS is an exoprotein, which is secreted into the extracellular environment in a ZirT-dependent manner. The ZirTS secretion pathway was found to share several important features with two-partner secretion (TPS) systems and members of the intimin/invasin family of adhesions. We show that zirTS expression is affected by zinc; and that in vivo, induction of zirT occurs distinctively in Salmonella colonizing the small intestine, but not in systemic sites. Additionally, strong expression of zirT takes place in Salmonella shed in fecal pellets during acute and persistent infections of mice. Inactivation of ZirTS results in a hypervirulence phenotype of Salmonella during oral infection of mice. Cumulatively, these results indicate that the ZirTS pathway plays a unique role as an antivirulence modulator during systemic disease and is involved in fine-tuning a host-pathogen balance during salmonellosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.