ArticleAmerican journal of respiratory and critical care medicine2008
Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthma.
Article in American journal of respiratory and critical care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness.PloS one · 2015Trial
- Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: results of a double-blinded randomized cross-over clinical pilot study.Particle and fibre toxicology · 2014Trial
- Circulating conventional and plasmacytoid dendritic cell subsets display distinct kinetics during in vivo repeated allergen skin challenges in atopic subjects.BioMed research international · 2014Trial
- Innate Immunity and Asthma Exacerbations: Insights From Human Models.Immunological reviews · 2025Review
- Microbes little helpers and suppliers for therapeutic asthma approaches.Respiratory research · 2024Review
- Air pollutants and early origins of respiratory diseases.Chronic diseases and translational medicine · 2018Article
- Enhanced antigen presenting and T cell functions during late-phase allergic responses in the lung.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Chronic exposure to indoxacarb and pulmonary expression of toll-like receptor-9 in mice.Veterinary world · 2016Article
- House Dust Mite Allergens and the Induction of Monocyte Interleukin 1β Production That Triggers an IκBζ-Dependent Granulocyte Macrophage Colony-Stimulating Factor Release from Human Lung Epithelial Cells.American journal of respiratory cell and molecular biology · 2015Article
- Linking Endotoxins, African Dust PM10 and Asthma in an Urban and Rural Environment of Puerto Rico.Mediators of inflammation · 2015Article
- Exploring the boundaries of systemic inflammation*.Critical care medicine · 2014Article
- Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics.BMC immunology · 2014Article
- Expression of Toll-like receptor 9 in mouse and human lungs.Journal of anatomy · 2013Article
- Ragweed pollen extract intensifies lipopolysaccharide-induced priming of NLRP3 inflammasome in human macrophages.Immunology · 2013Article
- Article
- Assessment of immunotoxicity using precision-cut tissue slices.Xenobiotica; the fate of foreign compounds in biological systems · 2013Review
- Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Effect of prostaglandin I2 analogs on cytokine expression in human myeloid dendritic cells via epigenetic regulation.Molecular medicine (Cambridge, Mass.) · 2012Article
- Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans.American journal of respiratory and critical care medicine · 2011Article
- Prostaglandin I(2) analogues enhance growth-related oncogene-alpha expression in human monocyte-derived dendritic cells.Inflammation · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleEpidemiologic studies have shown that exacerbation of asthma is modulated by environmental endotoxin. High levels of endotoxin are associated with asthma symptoms and the current use of asthma medication. However, the underlying mechanisms by which endotoxin modulates asthma are not completely understood.
objectivesThe aim of the study was to test whether endotoxin enhances the response of individuals with allergic asthma to allergen, and to determine if this interaction is associated with increased numbers of antigen-presenting cells in the airways.
methodsSeventeen subjects with mild allergic asthma underwent segmental challenge with allergen, endotoxin, and the combination of both in three different lung segments via bronchoscopy. The cellular influx including monocytes, myeloid dendritic cells (mDCs), and plasmacytoid dendritic cells (pDCs), as well as the level of cytokines, were assessed in bronchoalveolar lavage fluid obtained 24 hours after segmental challenge. Monocytes, mDCs, and pDCs were isolated and their capacity to induce T cell proliferation was determined. MEASUREMENTS AND MAIN
resultsEndotoxin enhanced the cellular response to allergen. The combination of allergen and endotoxin resulted in increased numbers of total cells, lymphocytes, neutrophils, eosinophils, monocytes, and mDCs, as well as increased levels of lipopolysaccharide-binding protein, IL-1alpha, IL-6, and tumor necrosis factor-alpha in the bronchoalveolar lavage fluid compared with allergen alone. Isolated mDCs but not pDCs induced a strong T cell proliferation in vitro.
conclusionsEndotoxin augments the allergic inflammation in the lungs of individuals with asthma, and induces an enhanced influx of monocytes and functionally active antigen-presenting mDCs into the respiratory tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.