ArticleAmerican journal of respiratory and critical care medicine2008
Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice.
Article in American journal of respiratory and critical care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Do antiepileptic drugs increase the risk of infectious diseases? A meta-analysis of placebo-controlled studies.British journal of clinical pharmacology · 2017Pooled it
- Phosphorothioate backbone modification of oligodeoxynucleotides induces TLR9-independent lung epithelial antimicrobial responses.American journal of respiratory cell and molecular biology · 2026Article
- Advances in Interleukin-6 Family Cytokines and the Role in Respiratory Diseases.Journal of inflammation research · 2025Review
- The RNA receptor RIG-I binding synthetic oligodeoxynucleotide promotes pneumonia survival.JCI insight · 2024Article
- Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial immunometabolic modulation.PLoS pathogens · 2023Article
- Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial metabolic reprogramming.bioRxiv : the preprint server for biology · 2023Article
- Pre-exposure to Aerosolized Polyvalent Bacterial Lysates Protects Against Bleomycin-Induced Pulmonary Fibrosis in Mice.Inflammation · 2022Article
- The effect of aerosolized bacterial lysate on experimentally inducedCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2022Article
- Epithelial immunomodulation by aerosolized Toll-like receptor agonists prevents allergic inflammation in airway mucosa in mice.Frontiers in pharmacology · 2022Article
- Acceptability of a Sublingual Drug Formulation for Respiratory Tract Infections in Children Aged 3 to 5 Years.Pharmaceutics · 2021Article
- Host-directed therapy in foals can enhance functional innate immunity and reduce severity of Rhodococcus equi pneumonia.Scientific reports · 2021Article
- The Role of Innate Immunity in Pulmonary Infections.BioMed research international · 2021Review
- Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia.Frontiers in immunology · 2021Article
- IL-6 Deficiency Exacerbates Allergic Asthma and Abrogates the Protective Effect of Allergic Inflammation againstJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Pulmonary and systemic responses to aerosolized lysate of Staphylococcus aureus and Escherichia coli in calves.BMC veterinary research · 2020Article
- Inducible epithelial resistance against acute Sendai virus infection prevents chronic asthma-like lung disease in mice.British journal of pharmacology · 2020Article
- Broad-spectrum suppression of bacterial pneumonia by aminoglycoside-propagated Acinetobacter baumannii.PLoS pathogens · 2020Article
- Animal Models ofInternational journal of molecular sciences · 2019Review
- One-hit wonder: Late after burn injury, granulocytes can clear one bacterial infection but cannot control a subsequent infection.Burns : journal of the International Society for Burn Injuries · 2019Article
- Host-pathogen kinetics during influenza infection and coinfection: insights from predictive modeling.Immunological reviews · 2018Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
rationaleThe lungs are a common site of serious infection in both healthy and immunocompromised subjects, and the most likely route of delivery of a bioterror agent. Since the airway epithelium shows great structural plasticity in response to inflammatory stimuli, we hypothesized it might also show functional plasticity.
objectivesTo test the inducibility of lung defenses against bacterial challenge.
methodsMice were treated with an aerosolized lysate of ultraviolet-killed nontypeable (unencapsulated) Haemophilus influenzae (NTHi), then challenged with a lethal dose of live Streptococcus pneumoniae (Spn) delivered by aerosol. MEASUREMENTS AND MAIN
resultsTreatment with the NTHi lysate induced complete protection against challenge with a lethal dose of Spn if treatment preceded challenge by 4 to 24 hours. Lesser levels of protection occurred at shorter (83% at 2 h) and longer (83% at 48-72 h) intervals between treatment and challenge. There was also some protection when treatment was given 2 hours after challenge (survival increased from 14 to 57%), but not 24 hours after challenge. Protection did not depend on recruited neutrophils or resident mast cells and alveolar macrophages. Protection was specific to the airway route of infection, correlated in magnitude and time with rapid bacterial killing within the lungs, and was associated with increases of multiple antimicrobial polypeptides in lung lining fluid.
conclusionsWe infer that protection derives from stimulation of local innate immune mechanisms, and that activated lung epithelium is the most likely cellular effector of this response. Augmentation of innate antimicrobial defenses of the lungs might have therapeutic value.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.