ArticleEndocrinology2008
Autoimmune hypophysitis of SJL mice: clinical insights from a new animal model.
Article in Endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Idiopathic granulomatous hypophysitis: a systematic review of 82 cases in the literature.Pituitary · 2014Pooled it
- The Pituitary Immune Environment and Immunotherapy: From Hypophysitis to Pituitary Neuroendocrine Tumors.Cells · 2025Review
- Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid.Nature communications · 2025Article
- Inflammatory and Infectious Disorders in Endocrine Pathology.Endocrine pathology · 2023Review
- Preclinical models and evaluation criteria of prostatitis.Frontiers in immunology · 2023Review
- Inhibition of IRAK1 Is an Effective Therapy for Autoimmune Hypophysitis in Mice.International journal of molecular sciences · 2022Article
- Autoantibody reactivity profile of primary autoimmune hypophysitis patients: preliminary results.Endocrine · 2022Article
- Lymphocytic panhypophysitis and anti-rabphilin-3A antibody with pulmonary sarcoidosis.Pituitary · 2022Article
- Full recovery from chronic headache and hypopituitarism caused by lymphocytic hypophysitis: A case report.World journal of clinical cases · 2022Article
- Markers of humoral and cell-mediated immune response in primary autoimmune hypophysitis: a pilot study.Endocrine · 2021Article
- Th17 Cells Contribute to the Pathology of Autoimmune Hypophysitis.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Retro-inverso D-peptides as a novel targeted immunotherapy for Type 1 diabetes.Journal of autoimmunity · 2020Article
- Hypophysitis: An update on the novel forms, diagnosis and management of disorders of pituitary inflammation.Best practice & research. Clinical endocrinology & metabolism · 2019Review
- In Situ Activation of Pituitary-Infiltrating T Lymphocytes in Autoimmune Hypophysitis.Scientific reports · 2017Article
- Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects.Pituitary · 2016Review
- Immunotherapy and hypophysitis: clinical presentation, treatment, and biologic insights.Pituitary · 2016Review
- Autoimmune lymphocytic hypophysitis in association with autoimmune eye disease and sequential treatment with infliximab and rituximab.Pituitary · 2015Article
- Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis.The Journal of clinical endocrinology and metabolism · 2015Article
- CD4+ cells, macrophages, MHC-I and C5b-9 involve the pathogenesis of dysferlinopathy.International journal of clinical and experimental pathology · 2015Article
- Endocrine-related adverse events following ipilimumab in patients with advanced melanoma: a comprehensive retrospective review from a single institution.Endocrine-related cancer · 2014Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Autoimmune hypophysitis (AH) is a rare but increasingly recognized disease of the pituitary gland. Its autoantigens are unknown, and the management is difficult because it is often misdiagnosed as a nonsecreting adenoma. By immunizing female SJL/J mice with mouse pituitary extracts, we established a new mouse model of experimental AH. Immunized mice developed severe lymphocytic infiltration in the anterior pituitary that closely mimicked the human pathology. In the early phase of experimental AH, the pituitary enlarged, consistent with the compression symptoms reported by hypophysitis patients at presentation. In the florid phase, adrenal insufficiency and pituitary antibodies developed, in strong correlation with the pituitary pathology. In the late phase, hypothyroidism ensued, and the pituitary gland became atrophic. Using immune sera as probes in a two-dimensional immunoblotting screen followed by mass spectrometry, we identified several proteins that could function as pituitary autoantigens. These findings provide new insights into the pathogenesis of AH, and establish a platform for developing novel diagnostic biomarkers and therapeutics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.