ArticleVeterinary immunology and immunopathology2008
Gastric Helicobacter species as a cause of feline gastric lymphoma: a viable hypothesis.
Article in Veterinary immunology and immunopathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 82 citations in OpenAlex.
- What Does Bacteria Have to Do with Cancer? The Influence of the Body's Microbiota on Cancer in Cats and Dogs.International journal of molecular sciences · 2026Review
- Feline Alimentary Lymphomas: Established Concepts and an Underexplored Molecular Landscape.Current issues in molecular biology · 2026Review
- Presence of potentially novel Helicobacter pylori-like organisms in gastric samples from cats and dogs.Veterinary research · 2023Article
- Feline Lymphoma: Patient Characteristics and Response Outcome of the COP-Protocol in Cats with Malignant Lymphoma in The Netherlands.Animals : an open access journal from MDPI · 2023Article
- Infectious Causes of Neoplasia in the Domestic Cat.Veterinary sciences · 2022Review
- Pegylated asparaginase in feline high-grade lymphoma: clinical results of single injection and continued incorporation into a modified COP regimen.Journal of feline medicine and surgery · 2022Article
- Gastric Helicobacter species associated with dogs, cats and pigs: significance for public and animal health.Veterinary research · 2022Review
- Association of gastric lymphofollicular hyperplasia with Helicobacter-like organisms in dogs.Journal of veterinary internal medicine · 2022Article
- Endoscopic Biopsies and Histopathological Findings in Diagnosing Chronic Gastrointestinal Disorders in Dogs and Cats.Veterinary medicine international · 2020Review
- Feline low-grade alimentary lymphoma: an emerging entity and a potential animal model for human disease.BMC veterinary research · 2018Review
- Cancer in wildlife: patterns of emergence.Nature reviews. Cancer · 2018Review
- Relationship of the mucosal microbiota to gastrointestinal inflammation and small cell intestinal lymphoma in cats.Journal of veterinary internal medicine · 2018Article
- Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models.Disease models & mechanisms · 2017Review
- Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma.Helicobacter · 2016Article
- Pathogenic properties of enterohepatic Helicobacter spp. isolated from rhesus macaques with intestinal adenocarcinoma.Journal of medical microbiology · 2014Article
- Diagnostic laparoscopy in the cat: 1. Rationale and equipment.Journal of feline medicine and surgery · 2014Review
- A mixed population of Helicobacter pylori, Helicobacter bizzozeronii and "Helicobacter heilmannii" in the gastric mucosa of a domestic cat.Irish veterinary journal · 2014Article
- Mechanisms, causes, investigation and management of vomiting disorders in cats: a literature review.Journal of feline medicine and surgery · 2013Review
- Feline idiopathic inflammatory bowel disease: what we know and what remains to be unraveled.Journal of feline medicine and surgery · 2012Review
- Feline alimentary lymphoma: 1. Classification, risk factors, clinical signs and non-invasive diagnostics.Journal of feline medicine and surgery · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Gastric Helicobacter spp. are associated with chronic inflammation and neoplastic transformation in humans as well as domestic and laboratory species. The present study examined the association of Helicobacter heilmannii (Hhe) infection in pet cats with feline gastric mucosa associated lymphoid tissue (MALT) lymphoma. Tissues were collected via gastric biopsy or at necropsy from 47 pet cats with clinical signs of gastrointestinal disease, including vomiting and inappetance, and classified as gastritis (14/47), lymphoma (31/37), or normal (2/47). Tissues positive for argyrophilic organisms with Warthin-Starry stain (29/47) were assessed by fluorescent in situ hybridization (FISH) for the presence of Hhe strains 1-4 as well as with a fifth probe that detected Helicobacter salomonis, Helicobacter bizzozeronii, or Helicobacter felis. A significant association of positive Warthin-Starry status with Hhe infection was found in cases of sick cats (22/29; p<0.05 by Chi-square; chi(2)=7.034). Interestingly, a significant association between Hhe status and a diagnosis of lymphoblastic or lymphocytic lymphoma was observed as well in a subset of 24 Warthin-Starry positive lymphoma cases: of lymphoblastic lymphoma cases, 13/17 were positive for Hhe (p<0.05; chi(2)=4.854). Hhe strains 2 and 4 were most commonly found (18/29 and 17/29, respectively) among sick cats, although a higher than expected number of cats was also positive for Hhe1, which initial reports have described as rare in cats and common in humans. The association found between a positive Hhe status with the presence of feline gastric lymphoma, especially lymphoblastic lymphoma, argues for the need to conduct prospective studies to better identify the frequency and strain distribution of Hhe infection in both healthy and clinically ill cats, particularly those cats with gastric lymphoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.