ReviewHormones and behavior2008
Androgen regulation of axon growth and neurite extension in motoneurons.
Review in Hormones and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Neurological Effects ofNutrients · 2026Article
- Sex differences in functional and structural alterations of hippocampus region in chronic pain: a DTI and resting-state fMRI study.Frontiers in neuroscience · 2024Article
- Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy.Cell death & disease · 2022Article
- Mapping Motor Neuron Vulnerability in the Neuraxis of Male SOD1Frontiers in endocrinology · 2022Article
- The role of ubiquitination in spinal and bulbar muscular atrophy.Frontiers in molecular neuroscience · 2022Review
- Pubertal Testosterone and the Structure of the Cerebral Cortex in Young Men.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Androgen Therapy in Neurodegenerative Diseases.Journal of the Endocrine Society · 2020Review
- The Role of Sex and Sex Hormones in Neurodegenerative Diseases.Endocrine reviews · 2020Review
- Androgen receptor antagonism accelerates disease onset in the SOD1British journal of pharmacology · 2019Article
- Predictive Factors of Efficacy Maintenance after Testosterone Treatment Cessation.Journal of clinical medicine · 2019Article
- Protective effects of gonadal hormones on spinal motoneurons following spinal cord injury.Neural regeneration research · 2018Review
- Protective Effects of Estradiol and Dihydrotestosterone following Spinal Cord Injury.Journal of neurotrauma · 2018Article
- Neurotrophic and Neuroregenerative Effects of GH/IGF1.International journal of molecular sciences · 2017Review
- Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits.BioMed research international · 2017Article
- Neuroregenerative Effect of Oxandrolone: A Case Report.The American journal of case reports · 2015Article
- Cross-talk between androgen receptor/filamin A and TrkA regulates neurite outgrowth in PC12 cells.Molecular biology of the cell · 2015Article
- Mechanisms mediating spinal and bulbar muscular atrophy: investigations into polyglutamine-expanded androgen receptor function and dysfunction.Frontiers in neurology · 2013Article
- Neuroprotective effects of testosterone on motoneuron and muscle morphology following spinal cord injury.The Journal of comparative neurology · 2012Article
- Disruption of nongenomic testosterone signaling in a model of spinal and bulbar muscular atrophy.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Androgens act on the CNS to affect motor function through interaction with a widespread distribution of intracellular androgen receptors (AR). This review highlights our work on androgens and process outgrowth in motoneurons, both in vitro and in vivo. The actions of androgens on motoneurons involve the generation of novel neuronal interactions that are mediated by the induction of androgen-dependent neurite or axonal outgrowth. Here, we summarize the experimental evidence for the androgenic regulation of the extension and regeneration of motoneuron neurites in vitro using cultured immortalized motoneurons, and axons in vivo using the hamster facial nerve crush paradigm. We place particular emphasis on the relevance of these effects to SBMA and peripheral nerve injuries.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.