ArticleAmerican journal of human genetics2008
On the replication of genetic associations: timing can be everything!
Article in American journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00021840 (Genetic Epidemiology of Asthma in Costa Rica), which is not on this map. Cited by 82 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Asthma in Costa Rica
Who cites it
82 citing papers in PubMed, 8 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Genetic background and immune response in paracoccidioidomycosis: A systematic review and meta-analysis of single nucleotide variants.PLoS neglected tropical diseases · 2026Pooled it
- Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores.Genetic epidemiology · 2022Pooled it
- Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.International journal of obesity (2005) · 2021Pooled it
- Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.Human molecular genetics · 2013Pooled it
- Genetic polymorphisms for estimating risk of atrial fibrillation: a literature-based meta-analysis.Journal of internal medicine · 2012Pooled it
- Common genetic determinants of vitamin D insufficiency: a genome-wide association study.Lancet (London, England) · 2010Pooled it
- Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.PLoS genetics · 2010Pooled it
- A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.Human molecular genetics · 2010Pooled it
- Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.BMC medical genetics · 2011Trial
- An evaluation of age-varying genetic effects underlying body-mass index and blood pressure in the UK Biobank.PLoS genetics · 2026Article
- Genome-wide association identifies novel ROP risk loci in a multiethnic cohort.Communications biology · 2024Article
- The impact of age on genetic risk for common diseases.PLoS genetics · 2021Article
- Genetic and environmental influences on the developmental trajectory of callous-unemotional traits from childhood to adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2021Article
- Association of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts.PloS one · 2020Article
- Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Observational
- Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Article
- Comparison of SNP Genotypes Related to Proliferative Vitreoretinopathy (PVR) across Slovenian and European Subpopulations.Journal of ophthalmology · 2018Article
- Association analysis of dyslexia candidate genes in a Dutch longitudinal sample.European journal of human genetics : EJHG · 2017Article
- Transferability of genome-wide associated loci for asthma in African Americans.The Journal of asthma : official journal of the Association for the Care of Asthma · 2017Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 15 institutions in 6 countries.
Funding
Abstract
The failure of researchers to replicate genetic-association findings is most commonly attributed to insufficient statistical power, population stratification, or various forms of between-study heterogeneity or environmental influences.(1) Here, we illustrate another potential cause for nonreplications that has so far not received much attention in the literature. We illustrate that the strength of a genetic effect can vary by age, causing "age-varying associations." If not taken into account during the design and the analysis of a study, age-varying genetic associations can cause nonreplication. By using the 100K SNP scan of the Framingham Heart Study, we identified an age-varying association between a SNP in ROBO1 and obesity and hypothesized an age-gene interaction. This finding was followed up in eight independent samples comprising 13,584 individuals. The association was replicated in five of the eight studies, showing an age-dependent relationship (one-sided combined p = 3.92 x 10(-9), combined p value from pediatric cohorts = 2.21 x 10(-8), combined p value from adult cohorts = 0.00422). Furthermore, this study illustrates that it is difficult for cross-sectional study designs to detect age-varying associations. If the specifics of age- or time-varying genetic effects are not considered in the selection of both the follow-up samples and in the statistical analysis, important genetic associations may be missed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.